Heart failure (HF) alters the bone marrow (BM), reducing protective cells that regulate inflammation, reports a study conducted at Science Tokyo. According to the study, cardiac stress reduces a population of mesenchymal stromal cells that produces heparin-binding EGF-like growth factor. The resulting reduction in protective signaling alters blood-forming stem cells and promotes inflammatory macrophages. The findings identify the BM niche as an important regulator of lasting immune changes associated with HF, suggesting potential targets for future therapies.

A new research paper was published in Volume 18 of Aging on Sept. 16, 2026, titled “Control theory of aging and longevity for gerotherapeutic drug discovery: state space, vector fields, modalities, safety, and the minimum safe cost of functional restoration.”

AUSTIN, Texas — [Thursday, October 15, 2026] — TAMEST (Texas Academy of Medicine, Engineering, Science and Technology) today announced that the late Pete Winstead and Winstead PC law firm have been selected as recipients of the 2027 Kay Bailey Hutchison Distinguished Service Award. The award recognizes their extraordinary leadership, service and enduring contributions to research, discovery and innovation in Texas.

Even a local mRNA injection can produce unwanted expression in the liver. Researchers have redesigned the lipid nanoparticles that carry mRNA to reduce this spillover in mice while preserving expression in injected muscle. The formulation also supports repeated dosing and improves the confinement of expression after local brain and eye delivery.

Umbilical cord blood is more than a source of stem cells for transplantation. A review in Science China Life Sciences examines how its diverse cells and bioactive components are being explored for cancer immunotherapy, inherited disorders and tissue repair. The authors connect these opportunities with advances in cell expansion, gene engineering and manufacturing, while identifying barriers to clinical translation. They emphasize that many emerging applications still require further evidence of safety, effectiveness and durable benefit.

Researchers at the Institute of Industrial Science, The University of Tokyo have developed MatterGen-e^-, a machine learning model for the inverse design of inorganic crystals. The model generates crystal structures with electronic-structure descriptors to match a target property, producing more valid, stable, unique, and novel structures than when the crystal structure is considered alone. Control experiments showed that only physically meaningful electronic descriptors improve stability and validity, whereas diversity increased regardless of the descriptors used.

Researchers have achieved high-fidelity control of multiple silicon spin qubits operating in parallel. Using a five-qubit silicon array controlled through a single shared microwave line, they identified a key source of errors during the simultaneous operation of qubits and developed a way to mitigate its effects. This shows that high-fidelity control can be maintained even when several qubits are operated at the same time and represents an important step toward scaling up silicon-based quantum processors.

Kyoto, Japan -- Structural metals used in engineering projects are expected to have both high strength and high ductility: an ability to withstand heavy loads and deform before failure. Achieving both of these properties at the same time, however, is challenging.

An important measure of ductility is uniform elongation, or the amount of deformation a metal can sustain before it concentrates in one small area, resulting in a fracture. Some metals become stronger as they are deformed -- a phenomenon known as strain hardening -- so if a material can continue to harden sufficiently during deformation, theoretically uniform stretching can be maintained. However, a metal's effectiveness usually decreases as deformation continues. While some advanced metals obtain additional strain hardening from deformation-twinning and martensitic transformation, these processes tend to compete with each other, so metals are commonly designed to rely predominantly on just one or the other.

A team of researchers at Kyoto University wondered if both mechanisms could be activated in the same material at different stages of deformation, and hypothesized this could cause strains to harden sequentially rather than compete with each other. They proposed a strategy in which different deformation mechanisms are activated in sequence, with each providing additional strain hardening as the previous step becomes less effective.