Single-cell atlas reveals why rotator cuff injuries heal with damaging scars
Peer-Reviewed Publication
Updates every hour. Last Updated: 4-Apr-2026 11:15 ET (4-Apr-2026 15:15 GMT/UTC)
Rotator cuff tears often heal with stiff, dysfunctional scar tissue, limiting recovery. A new study reveals why tendon regeneration fails after injury. Using single-cell profiling of tens of thousands of cells from patient tendon samples, the study maps the first atlas of human tendon scarring and identifies pro-fibrotic stem cells, senescent tendon cells, scar-forming macrophages, and transitioning endothelial cells. Targeting key fibrotic signals reduced scarring in animal models, suggesting new therapeutic strategies.
Flexible electronics have been drawing significant attention for healthcare applications and show great promise for monitoring of blood circulation (e.g., postoperative monitoring of free flaps). However, existing methods for design and fabrication of interfaces with human skin still cannot meet the challenging clinical requirements of superior adhesion during monitoring and avoiding wound damage during peel-off. Now, writing in the journal National Science Review, a team of researchers from China and Singapore proposes a soft biosensor with universal responsive hydrogel interfaces for detecting blood circulation complications. They develop thermoresponsive and printable hydrogel inks to achieve rapidly high-precision patterning and wide-range adhesion regulation of interface layers. In clinical cases, the hydrogel biosensor can establish robust hydrogel/flap skin coupling for high-fidelity signal acquisition during monitoring, and ensure benign detachment to prevent tissue injury after monitoring. They achieve precise arterial perfusion monitoring based on the perfusion index (PI) via an 810 nm light source. Additionally, they propose a new metric, the balance index (BI), to monitor venous congestion. By analyzing BI, PI, and skin temperature, the biosensor enables accurate detection and differentiation of blood circulation complications.
A research paper just published in Science China Life Sciences reveals how microbes and soil properties respond to drought stress and subsequent recovery in the urban green space. Researchers found that while drought significantly altered microbial communities and enhanced multifunctionality, the drivers of the multifunctionality shifted fundamentally during recovery. Regulation transits from biotic factors during drought to soil properties after rehydration. This insight is vital for managing urban ecosystem resilience against climate change.
A research team from Huazhong University of Science and Technology has developed a novel orbital modulation strategy to suppress anti-site defects in NASICON-type Na3MnTi(PO4)3 cathode for sodium-ion batteries. By Li doping to construct Li–O–Mn configuration, the strategy effectively enhances Mn–O covalent interaction and elevates Mn defect formation energy, thus eliminating voltage hysteresis caused by anti-site defects. The optimized Na2.97Li0.03MnTi(PO4)3 cathode achieves ultra-long cycling stability, excellent rate performance and wide-temperature adaptability, and the assembled pouch-type full cell further verifies its practical application potential. This study provides a new electronic structure regulation approach for the design of high-performance sodium-ion battery cathodes, paving the way for the development of low-cost and sustainable energy storage technologies.
What if nature’s tiny wonders—waterspider legs and fish scales—hold the key to better energy storage? Researchers have turned these biological structures into a Janus air electrode, unlocking zinc-air batteries with 239.3 mW cm−2 peak power density and exceptional cycling stability.
Magnetically steerable guidewires enable remote, minimally invasive navigation and precise tip control in complex vasculature. Scientists at Nankai University developed a dual-coil magnetic guidewire robot with independently driven distal microcoils that switch among three modes. Dual-attraction and dual-repulsion provide large-range curvature tuning and better axial force transmission for smoother advancement, while the spoon-shaped mode delivers gradual, continuous bending for safer branch entry. The approach enables reliable, controllable robotic endovascular navigation.