22-Jul-2025
How tickling builds trust: Scientists identify oxytocin’s role in human-rat bonding
Okayama UniversityPeer-Reviewed Publication
Juvenile-adolescent rats produce ultrasonic vocalizations characteristic of a pleasant sensation in response to repeated tickling by human hands. This interaction, which mimics natural rough-and-tumble play, is thought to be pleasure-inducing and lead to affinity-like behavior in rats. Researchers have now found that increased expression in a key brain region drives affinity-like behavior and identified neurons involved in the social bonding process. The findings offer crucial insights into the neural basis of cross-species bonding.
- Journal
- Current Biology
- Funder
- Japan Society for the Promotion of Science (JSPS) KAKENHI, Japan, Takeda Science Foundation, Naito Foundation, Ryobi Teien Memory Foundation, Wesco Scientific Promotion Foundation, Japan, Toyo Suisan Foundation, Japan Foundation for Applied Enzymology, JST SPRING, Japan, Synergy European Research Council (ERC) grant ‘‘OxytocINspace’’, SFB Consortium, German-Israeli Project cooperation (DIP)