The 2024 WHO Bacterial Priority Pathogens List (WHO BPPL) is a critical tool for refining global antimicrobial resistance (AMR) strategy, prioritizing 24 bacteria with a focus on Gram-negatives and community threats like Salmonella Typhi. This perspective examines its One Health implications. While the 2024 WHO BPPL effectively guides research and development (R&D), policy, and infection control through vaccines and water, sanitation and hygiene (WASH) programs, its human-centric approach underrepresents critical agricultural and environmental AMR drivers. Surveillance biases towards high-income countries and the inherent challenges of cross-sectoral monitoring—given the distinct niches of pathogens like Enterococcus faecium and Shigella—further limit its scope. We call for integrating zoonotic and environmental metrics, strengthening global surveillance (e.g., Global Antimicrobial Resistance and Use Surveillance System [GLASS]), and accelerating development of novel therapies to advance a more equitable and holistic AMR response.

A new peer-reviewed study evaluating climate policies in 40 countries over a 32-year period finds that carbon pricing and taxation—combined with investments in renewable energy and research—are among the most effective tools governments can use to reduce CO₂ emissions.

In a Policy Forum, Joshua Lappen and Emily Grubert discuss the unseen infrastructural threats that may arise as fossil energy systems are phased out. According to the authors, acknowledging and planning for limits in the “minimum viable scale” of fossil fuel systems is essential to achieving a safe, just, and credible transition to a low-carbon energy future. The global energy transition relies on two parallel processes – building new low-carbon systems while carefully winding down the fossil-fuel infrastructure that has long powered humanity. To date, research and policy have focused great attention on growth and replacement and far less on how firmly entrenched legacy fossil fuel-based energy systems behave as they shrink. According to Lappen and Grubert, this neglect is risky because such systems may fail once they fall below a minimum viable scale, the point at which their physical, financial, and managerial foundations can no longer operate as expected, triggering service collapses, safety hazards, economic shocks, and environmental harm. This could erode public trust in the energy transition itself.  Minimum viable scales may be much larger and closer than commonly recognized, say the authors. Here, Lappen and Grubert evaluate the constraints that underlie the minimum viable scale of several key components of the fossil fuel economy, including petroleum refineries, natural gas pipelines, and coal-fired electric services. They highlight how the failure of a single component can cascade across these highly interdependent networks. The authors argue that improved modeling and coordinated planning can mitigate these risks.

Podcast: A segment of Science's weekly podcast with Joshua Lappen and Emily Grubert, related to this research, will be available on the Science.org podcast landing page [http://www.science.org/podcasts] after the embargo lifts. Reporters are free to make use of the segments for broadcast purposes and/or quote from them – with appropriate attribution (i.e., cite "Science podcast"). Please note that the file itself should not be posted to any other Web site.

A UBC research team has revealed substantial, ongoing inequities in how sex and gender are represented in exercise physiology—both in who is studied and who is conducting that research.

The analysis shows that exercise physiology continues to focus mainly on male bodies and voices, despite long-standing calls for greater equity. It also shows that these patterns are more pronounced in exercise physiology than in most other areas of health research