A new study from Tel Aviv University overturns prevailing scientific beliefs that King Solomon’s mines not only harmed the health of workers in the ancient copper industry but also pose risks to the health of modern residents living near the site.

A multicenter phase II trial has demonstrated that a combination of pyrotinib and fulvestrant offers significant antitumor activity and acceptable safety for hormone receptor-positive (HR+)/HER2-positive metastatic breast cancer patients who have developed resistance to trastuzumab. The study revealed a median progression-free survival (PFS) of 18.2 months and a disease control rate (DCR) of 97.5%, highlighting a novel therapeutic strategy for this challenging patient population.A multicenter phase II trial has demonstrated that a combination of pyrotinib and fulvestrant offers significant antitumor activity and acceptable safety for hormone receptor-positive (HR+)/HER2-positive metastatic breast cancer patients who have developed resistance to trastuzumab. The study revealed a median progression-free survival (PFS) of 18.2 months and a disease control rate (DCR) of 97.5%, highlighting a novel therapeutic strategy for this challenging patient population.

Published in the journal Scientific Reports, researchers have created realistic, skin-like replicas made of Ecoflex, a type of silicone rubber that can potentially serve as a platform to evaluate risks of bacterial infections from intravenous catheters and test wearable sensors, among other biomedical applications. The study found that EcoFlex-based skin replicas can be engineered to mimic actual skin textures, wettability, and elasticity, simulating the conditions where bacteria grow and adhere.

A research team co-led by a physician-scientist at the University of Arizona College of Medicine – Tucson’s Sarver Heart Center found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heart failure. The results were published in the journal Circulation.