Colon cancer is often driven by cancer stem cells, which resist treatment and lead to relapse. In a recent study, researchers from Japan revealed how transcription factors CDX1 and CDX2 suppress cancer cell stemness by blocking β-catenin’s ability to activate key genes like LGR5. Their findings showed that CDX1/2 prevent the formation of key transcriptional complexes involving DSIF and PAF1, identifying these as critical regulators and potential therapeutic targets in colon cancer.

Results of a study led by VHIO’s Prostate Cancer Group suggest that treatment with CDK4/6 inhibitors followed by senloytic therapies and PARP inhibitors could improve outcomes and combat cancer drug resistance in advanced prostate cancer.

Dr. Hamilton Se-Hwee Oh at Mount Sinai in New York pioneers research linking differential organ aging to depression and Alzheimer's disease. His Stanford PhD work yielded breakthrough Nature publications showing organs age at different rates. Now investigating how psychological stress accelerates aging and how peripheral signals rewire brain circuits affecting mood and cognition.