City of Hope^® Research Spotlight offers a glimpse into groundbreaking scientific and clinical discoveries advancing lifesaving cures for patients with cancer, diabetes and other chronic, life-threatening diseases. Each spotlight features research-related news, such as recognitions, collaborations and the latest research defining the future of medical treatment.

Shrimp processing waste, often discarded as low-value by-product, may hold untapped therapeutic potential. In a recent study, researchers identified five antioxidant peptides from shrimp by-products, with HFVPVYEGF and EGYPFNPLL showing the most potent protective effects against oxidative damage. These peptides demonstrated the ability to reduce reactive oxygen species (ROS), boost antioxidant enzyme activity, and significantly enhance the viability of human liver cells (HepG2) under oxidative stress. The findings reveal a promising avenue for converting seafood waste into high-value bioactive ingredients with health-promoting functions.

Egg yolk, long known for its nutritional benefits, may hold the key to a natural treatment for osteoporosis. A groundbreaking study has found that water-soluble egg yolk fractions, particularly the FC1 subfraction (< 3 kDa), significantly inhibit osteoclastogenesis—the process responsible for bone resorption. This discovery, based on in vitro tests with RAW264.7 macrophages, shows that FC1 not only curbs osteoclast formation but also activates apoptosis in mature osteoclasts. With further research, these egg yolk-derived bioactive compounds could pave the way for safer, natural supplements to promote bone health, offering an alternative to traditional treatments with fewer side effects.