Cancer cachexia is commonly present in various cancers, including live, pancreatic, gastroesophageal, and bile duct cancers, and is associated with chemotherapy toxicity. M-MDSC induces mTEC apoptosis and impairs T cell negative selection, which leads to autoimmune T-cell infiltration of normal organs and serves as a prerequisite for the occurrence of irAEs. In addition, irAEs patients have higher levels of circulating M-MDSCs. M-MDSCs associated with cancer cachexia can serve as potential predictive biomarkers for irAE in advanced cancer patients.

Discover how human adipose tissue can be transformed into functional organoids representing all three germ layers—mesoderm, endoderm, and ectoderm—using a novel, streamlined method. This new study published in Engineering highlights the potential of adipose tissue for regenerative medicine, offering a scalable and clinically relevant alternative to traditional organoid generation techniques.

Discover how AI is revolutionizing RNA drug development in a new article published in Engineering. Learn about the potential of AI to enhance RNA therapies, address current limitations, and unlock new opportunities for personalized medicine. Explore the future of AI-driven drug discovery and its impact on healthcare.

Scientists have created a groundbreaking, fully implantable neurostimulator made entirely of soft hydrogel to treat inflammatory bowel disease (IBD). Unlike traditional rigid and wired implants, this wireless device gently wraps around the splenic nerve. It receives power through the skin to deliver electrical pulses that calm gut inflammation by rebalancing the immune system. In animal studies, the device significantly alleviated colitis symptoms without causing scar tissue formation, paving the way for a new class of soft, bioelectronic therapies for chronic diseases.

A recent study comprehensively evaluated the secondary metabolite diversity and in vitro antidiabetic activity of Sanghuangporus quercicola under various culture conditions, highlighting the medicinal fungus’s immense potential for developing new antidiabetic drugs and functional foods.

A new study published in Engineering reveals the global spread of tmexCD1-toprJ1-positive Klebsiella pneumoniae, highlighting its multidrug resistance and transmission across ecological niches. The research underscores the urgent need for antimicrobial stewardship and continuous monitoring to combat this emerging public health threat.