In an ecosystem that’s losing much of its biodiversity, mosquitoes might be shifting to a new food source. Researchers analyzed blood meals of mosquitoes captured in the Brazilian Atlantic Forest and found most meals contained human blood. This strong preference for humans could lead to mosquitoes transmitting more viral diseases and adverse health outcomes for people who live in the area. Studies like this one can contribute to better prevention actions, the team said.

Data from a major U.S. clinical trial from the Alliance for Clinical Trials in Oncology has uncovered a genetic factor that may inform how to optimize the dosing of abiraterone, a widely used hormone treatment for advanced prostate cancer. Published in Clinical and Translational Science, this secondary analysis of Alliance A032201 could lead to more personalized treatments for patients.

Using 3D bioprinting, researchers at UC San Diego, in collaboration with Allele Biotechnology, are developing transplantable human livers (derived from a patient's own cells) in a new project aiming to tackle the critical shortage of donor organs. The project is funded by up to $25.8 million by the Advanced Research Projects Agency for Health (ARPA-H). 

Texas Biomed researchers find that existing treatments control TB and HIV, but the immune system does not revert to normal, helping explain why people living with HIV remain susceptible to infections and underscoring the need for host-directed therapies.

A study led by IRB Barcelona and the IBMB-CSIC, reveals how the bacterium that causes cholera activates its virulence programme, uncovering a single amino acid as a critical contact point. The study opens new avenues for future therapies.

Using cryo-electron microscopy, researchers have solved five structures of the V. cholerae activation complex, revealing how virulence gene expression is triggered once the bacterium reaches the human intestine.

Researchers at IRB Barcelona and the IBMB-CSIC, in collaboration with EMBL Heidelberg and partners in the United States, mapped the infection process with unprecedented detail, unveiling how the cell’s transcription machinery is recruited to the DNA and virulence genes are transcribed.