While multidrug-resistant Candida auris poses a global threat to public health, the impact and mechanism of drug resistance on fungal virulence remain unclear. This study reveals that fluconazole-resistant C. auris exhibits enhanced fitness and resistance to macrophage killing under zinc deficiency by mobilizing intracellular zinc. The inhibition of gene encoding Zn(II)2Cys6 transcription factor 4 (ZCF4) contributes to C. auris resistance to macrophage killing by suppressing the PI3K-AKT- mTOR pathway and downstream matrix metalloproteinase-9 (MMP-9) activity. Dietary zinc deficiency promotes the virulence of fluconazole-resistant C. auris. This research provides a mechanistic understanding of host-fungal interactions and highlights zinc intervention as a potential nutrient intervention strategy against fungal infection.

A study by researchers at West Virginia University and two other university-affiliated medical centers found a greater-than-expected significance in the risk of adverse pregnancy outcomes, including gestational diabetes and preeclampsia, for women who spend more time sitting compared to those who include even light activity in their daily routines.

Games, shopping, social media, pornography: The Internet offers many temptations. While most people use the Internet in moderation, some develop addictive behaviors. A multicenter study with over 1,000 participants with and without problematic Internet use found that all participant groups showed a tendency to approach internet-related cues. However, this automatic and unconscious pull was significantly stronger among individuals with problematic Internet use. “This indicates that certain training programs can be developed to help affected individuals distance themselves from such stimuli,” says Professor Martin Diers of the Ruhr University Bochum Clinic for Psychosomatic Medicine and Psychotherapy, Germany. The study was published in the Journal of Behavioral Addictions on May 12, 2026.

In an Editorial, Vaughan C. Turekian, Executive Director of the Office of International Networks, Cooperation, and Security at the National Academies of Sciences, Engineering, and Medicine argues that science is entering a new phase. In an era of vast computational power, automated experiments, and AI, science will increasingly be built around integrated platforms that link data, models, computing, and instrumentation at scale. 

University Hospitals awarded PCORI funding to implement a telehealth-based program to treat complex psychiatric disorders by integrating behavioral health into primary care. The model includes a behavioral health coordinator and expands screening and treatment for conditions such as post-traumatic stress disorder.