Phase 1 clinical trial set to begin on first leishmaniasis vaccine
Reports and Proceedings
Updates every hour. Last Updated: 30-Oct-2026 00:16 ET (30-Oct-2026 04:16 GMT/UTC)
A phase 1 clinical trial testing the safety of a leishmaniasis vaccine is set to begin in the coming months – the first vaccine created to protect against the disfiguring skin disease common in tropical regions of the world and gaining ground in the United States. The researcher who led development of the vaccine is the senior author of a New England Journal of Medicine review article published last week describing the difficulties of treating most forms of the disease and reporting that the live vaccine, found to be safe in animals, is expected to be tested in humans later this year.
Rifampicin resistant tuberculosis is a major global health crisis. A new study shows that the most common rifampicin resistance mutation in tuberculosis rewires bacterial gene regulation in a way that creates specific metabolic vulnerabilities. The findings could guide the development of combination therapies designed not only to kill drug resistant tuberculosis, but to suppress drug resistance itself.
A combination of two widely available anti-rheumatic drugs offers the first effective and affordable treatment for patients with Sjögren’s disease with systemic disease activity, according to new results from a clinical trial that was coordinated by UMC Utrecht. The study showed that treatment with leflunomide and hydroxychloroquine reduced disease activity in patients with moderate-to-severe disease, while maintaining a favorable safety profile.
Using bibliometric analysis of more than 1,000 articles published between 2014 and 2024, a new study charts the first decade of the Journal of Big Data and its emergence as a leading global data science publication. The journal has surpassed 1,000 papers and nearly 65,000 citations. Researchers identified three core themes – big data infrastructure, machine and deep learning, and applications such as cybersecurity, healthcare analytics, and sentiment analysis – while highlighting the journal’s growing international reach and influence on data science and AI research.