Memory systems in the brain drive food cravings that could influence body weight
Peer-Reviewed Publication
Updates every hour. Last Updated: 10-May-2025 22:09 ET (11-May-2025 02:09 GMT/UTC)
A Monell Center-led research team identified, for the first time, the brain’s food-specific memory system and its direct role in overeating and diet-induced obesity. They found a specific population of neurons in the mouse brain that encode memories for sugar and fat, profoundly impacting food intake and body weight.
Yes.” Led by Monell Associate Member Guillaume de Lartigue, PhD, the research team identified, for the first time, the brain’s food-specific memory system and its direct role in overeating and diet-induced obesity.
Published in Nature Metabolism, they describe a specific population of neurons in the mouse brain that encode memories for sugar and fat, profoundly impacting food intake and body weight.Past studies have identified a loneliness-rumination-depression nexus. Rumination is defined as repetitive and intrusive negative thoughts and feelings, and loneliness as a gap between desired and actual social connections.
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The research team’s hypothesis for their study, entitled “A network analysis of rumination on loneliness and the relationship with depression”, which was recently published in Nature Mental Health, aimed to examine the connections that rumination would mediate the relationship between loneliness and depression, where a higher level of loneliness would be associated with more rumination, which would, in turn, link to a higher severity of depressive symptoms.
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