Antibiotic resistance in plant pathogens threatens sustainable crop protection, yet its molecular basis remains incompletely understood. This study reports that streptomycin resistance in Clavibacter michiganensis strain TX-0702 is mediated by a plasmid-borne aminoglycoside phosphotransferase, APH(3), encoded on an uncharacterized plasmid, pCM3. Functional and biochemical analyses demonstrate that APH(3) inactivates streptomycin through phosphorylation, establishing a phosphorylation-driven resistance mechanism in Gram-positive plant pathogens. Sequence analyses reveal that pCM3 carries mobile genetic elements, suggesting environmental dissemination of resistance genes in plant-associated microbes. These findings expand understanding of phytopathogen antibiotic resistance and highlight plant microbiomes as potential resistance gene sources with implications for agricultural, food, and human health safety.

What if a prosthetic hand could adapt to the person instead of the other way around? Researchers have developed a personalized AI-powered prosthetic system that combines custom 3D-printed wearable sleeves with soft magnetic sensors to decode each user’s unique muscle movements in real time. Designed for every individual’s anatomy, the technology delivers more natural, reliable control and remained highly accurate during repeated testing, offering a promising step toward prosthetic devices that feel more intuitive, comfortable and responsive.

Researchers led by Worcester Polytechnic Institute (WPI) Assistant Professor Jiawei Yang have designed a modular system that could potentially improve hydrogel implants in the body by customizing the materials for stiffness and functionality.

 

 

At left, hydrogels developed by Jiawei Yang and a team of researchers exhibit different colors according to their coatings. At right, a microscopic image of a hydrogel surface. Photos courtesy of Jiawei Yang. The system, described in the peer-reviewed journal Science Advances, uses coatings to treat the surface of hydrogels, which are flexible, water-loaded polymers. 

To reduce the number of Listeria infections, researchers at DTU are proposing a new labelling scheme designed to help consumers choose products that inhibit the growth of Listeria. 

Growing interest in psychedelic microdosing has raised questions about its potential use in attention-deficit/hyperactivity disorder (ADHD). A systematic review by researchers from Wroclaw Medical University found that current scientific evidence remains insufficient to support psychedelics as an effective treatment for ADHD. The authors identified only five eligible studies and conclude that larger, well-designed clinical trials are needed before psychedelics can be considered for clinical practice.

Artificial intelligence is beginning to transform not only drug discovery but also the design of advanced biomaterials. In a new study, researchers combined machine learning with laboratory validation to develop a data-driven strategy for identifying bioactive nucleoside hydrogels for periodontitis treatment. By integrating predictive modeling with innovative molecular scoring methods, the work aims to streamline biomaterial discovery and accelerate the development of targeted therapies for oral health applications.

Building on the achievements of the IMI (Innovative Medicines Initiative) T2EVOLVE project, the Association provides a permanent home for the expertise, networks, and collaborative spirit developed through five years of partnership among academia, healthcare providers, industry, regulators, patient representatives, and other key stakeholders. Its mission is to support the responsible development, evaluation, and implementation of advanced cell therapies by creating a neutral environment where stakeholders can work together on shared challenges and opportunities.