Mass General Brigham announces new AI company to accelerate clinical trial screening and patient recruitment
Business Announcement
Updates every hour. Last Updated: 21-Dec-2025 21:11 ET (22-Dec-2025 02:11 GMT/UTC)
Mass General Brigham is announcing the spinout of AIwithCare, a company founded by researchers who created a Retrieval-Augmented Generation (RAG)–based AI tool that greatly outperforms manual review in assessing patient eligibility for clinical trial enrollment. The tool, called RECTIFIER, analyzes data from electronic health records—including visit notes and clinical reports—and has the potential to expand patient access to trials and accelerate drug discovery.
Chronic cerebral arterial occlusion and moyamoya disease are significant causes of stroke, particularly in regions where advanced diagnostic tools are limited. This study from Rajavithi Hospital assessed a simple bypass protocol that uses mean transit time to identify candidates for single-barrel bypass surgery. Thirty patients were evaluated, and 80 percent showed postoperative improvement with high graft patency and minimal complications. The findings support mean transit time as an effective non-stress method for guiding surgical decision-making.
Alcohol use disorder and risky alcohol drinking habits are important for primary care providers to know about and address with patients; a new study shows natural language processing, a form of artificial intelligence, could help.
Hypertrophic chondrocytes are deeply involved in the growth of mammalian bones. Researchers find that these cells transform into multiple functional cell types, including those responsible for lengthening bones, maintaining the periosteum, and promoting the invasion of blood vessels that supply newly formed bone. Thrombospondin-4, a key signaling molecule produced by these cells, drives blood vessel formation. These findings open new avenues for enhancing bone repair and healing injured bones.
Epicardial adipose tissue, the layer of fat between the heart muscle and the outer heart lining, was assessed by cardiovascular magnetic resonance in patients with acute myocardial infarction. Patients with the largest volumes of epicardial adipose tissue showed the greatest injury to the heart muscle. Prospective validation is now warranted to assess whether epicardial adipose tissue volume could be used in cardiovascular risk assessment to identify high-risk patients.
Real-time monitoring of patient-ventilator asynchrony (PVA) and respiratory parameters is important in patients with severe pneumonia. In a recent study, researchers have developed a “Remote Ventilate View” platform, which automatically analyzes ventilator waveforms in real-time, identifies eight PVA subtypes, and calculates the overall asynchrony index. This represents a paradigm shift from qualitative, spot-check assessments to precise quantification and longitudinal monitoring of PVA throughout the entire ventilation course.