This study developed a bacterial cellulose (BC)-based delivery system for acne treatment, incorporating natural actives nisin and mandelic acid. The system demonstrated potent antibacterial activity against standard and skin-isolated strains, along with high antioxidant activity. BC provided controlled release of actives, peaking at 300 min, and maintained stability over 180 days. Low cytotoxicity and high biocompatibility were confirmed in fibroblast cells. This eco-friendly formulation aligns with Clean Beauty principles, offering a sustainable, skin-friendly alternative to conventional acne treatments. The integration of natural compounds within a biodegradable matrix represents a novel approach in dermocosmetics.

Physical fitness and self-efficacy are key determinants of adolescent health, influencing both physical well-being and psychological resilience. While each has been independently linked to positive outcomes, their potential interplay remains less understood. Now, a Pediatric Investigation study of 618 Spanish adolescents reports that cardiorespiratory fitness, lower-body strength, and speed-agility are modestly but consistently associated with self-efficacy in both directions, highlighting the value of integrating physical training with confidence-building strategies in schools.

Lasers cut precisely and without contact – ideal for surgery. The problem is that, in hard tissues such as bone, they are too slow and do not cut deep enough. Researchers at the University of Basel have now demonstrated a way to cut much deeper and faster with a surgical laser than with previous laser systems.

Keck Medicine of USC researchers may have discovered a way to break through this blood-brain barrier and make immune checkpoint inhibitors effective for patients with recurrent, high-grade astrocytoma, thus potentially extending patients’ lives.

Researchers from The University of Osaka have developed a mouse model for achondroplasia. The model identified the importance of a signaling molecule called FGFR3 and a pathway called CREB in regulating bone growth. This pathway is also at least partially responsible for the pathology associated with achondroplasia and impaired bone growth. Their findings advance our understanding of the process of bone growth and provide novel therapeutic targets for achondroplasia.