Prostate cancer is one of the most common cancers affecting men worldwide. However, planning personalized radiotherapy in the advanced stages of the disease still requires more precise tools. Researchers at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) have now tested a novel approach. A combination of two diagnostic imaging techniques could pave the way for personalized radiotherapy. The results of the study, funded by the Wilhelm Sander Foundation, have been published in the Journal of Medicinal Chemistry (DOI: 10.1021/acs.jmedchem.6c00161).

Researchers tracked longitudinal alterations in adipose and muscle tissue through routine CT scans. Worsening visceral fat tissue degeneration predicts complications for compensated chronic hepatitis B-related cirrhosis, while sustained muscle loss signals risk in decompensated patients.

Ulinastatin (UTI), a protein naturally found in human urine, exerts hepatoprotective effects by attenuating inflammation, oxidative stress, and cell death, and modulating immunity and hemostasis. This review synthesizes existing evidence on UTI's therapeutic potential across seven liver conditions, from sepsis-induced hepatic injury to liver cancer.

In 94,344 UK Biobank participants, accelerometry objectively classified 24-hour rest-activity timing phenotypes. Over a median 6.8 years, the night-active phenotype was associated with higher incident MDD and anxiety risk, while an early-morning-active phenotype was associated with lower MDD risk.

The findings offer association evidence and exploratory MRI clues, but they do not establish that changing activity timing prevents mental disorders. Randomized trials are needed.