From x chromosome silencing to therapy: New strategies for treating x-linked disorders
Peer-Reviewed Publication
Updates every hour. Last Updated: 28-Oct-2026 23:16 ET (29-Oct-2026 03:16 GMT/UTC)
A new review explores how advances in understanding X chromosome inactivation (XCI) are creating potential therapeutic opportunities for a range of X-linked genetic disorders, including Rett syndrome, Fabry disease, Duchenne muscular dystrophy, hemophilia, and others. The article examines the molecular mechanisms that control X chromosome silencing, the impact of skewed XCI on disease severity, emerging methods to measure XCI patterns, and experimental approaches aimed at reactivating beneficial genes on the inactive X chromosome.
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McGill University researchers have developed a new tool to identify heart disease risk in women earlier in life.
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“Heart disease is the leading cause of death in women, yet existing risk tools were developed in older populations and ignore factors unique to women,” said senior author Robert Platt, Professor in the Department of Epidemiology, Biostatistics, and Occupational Health and Director of the School of Population and Global Health.
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