A dual-action strategy: Everolimus alleviates ulcerative colitis via inflammation suppression and microbiota remodeling
Peer-Reviewed Publication
Updates every hour. Last Updated: 15-Dec-2025 05:11 ET (15-Dec-2025 10:11 GMT/UTC)
A study published in iMetaMed reveals that the mTOR inhibitor Everolimus treats ulcerative colitis through a two-pronged approach: inhibiting the CLEC4E inflammatory pathway in macrophages and promoting beneficial gut bacteria that produce propionic acid, thereby restoring the intestinal barrier.
Liver cancer remains a significant global health challenge with limited effective treatments. A new study published in Med Research utilizes multiomics analysis to reveal how the traditional medicinal plant Lobelia chinensis Lour (LCL) exerts potential anticancer effects. Researchers identified specific bioactive components in LCL that target key cell cycle proteins—CCNB1, CCNB2, and CDK1—thereby inhibiting tumor progression. These findings highlight the therapeutic potential of LCL and suggest new diagnostic markers for liver cancer prognosis.
A new Curtin University study has found people diagnosed with sarcoma – a cancer disproportionately affecting teenagers and young adults – are being left without the resources they urgently need.
A new editorial published in Med Research addresses the critical imbalance between rapid technological advancements and global health accessibility. The authors outline a vision for a new interdisciplinary platform designed to bridge the gap between basic research and clinical application, advocating for an open, collaborative ecosystem that ensures medical breakthroughs benefit populations worldwide, regardless of geographic or economic limitations.
A new review article published in Med Research explores the application of microcalorimetry to measure the "four properties" (cold, hot, warm, and cool) of Traditional Chinese Medicine (TCM). By interpreting these ancient concepts through modern thermodynamics and biological heat monitoring, researchers propose a standardized, scientific framework called the "Stylization of TCM" to enhance quality control, clinical safety, and international acceptance.
Primary malignant pericardial mesothelioma (PMPM) is an exceptionally rare and aggressive tumor originating in the lining of the heart. Due to its ambiguous symptoms and lack of specific guidelines, misdiagnosis is common and survival rates are low. A new expert consensus, published in the journal Med Research, synthesizes multicenter clinical expertise to establish the first standardized protocols for PMPM. The consensus highlights the necessity of multimodal imaging, molecular pathology, and the emerging role of immunotherapy in extending patient survival.
Pneumoconiosis remains a prevalent occupational disease with limited treatment options. A new review study elucidates the critical role of ferroptosis—a specific type of regulated cell death—in the progression of the disease. The researchers detail how silica dust triggers ferroptosis in lung cells and propose that targeting this mechanism with specific inhibitors could offer a novel and effective therapeutic strategy for slowing lung fibrosis and failure.