The American Association of Immunologists (AAI) today announced the launch of Immunology Explained, a public communications initiative designed to connect people everywhere with clear, science-based information about the immune system and its impact on health. Immunology Explained will cover a broad range of immunology topics including vaccines, autoimmunity, cancer immunotherapy, and infectious diseases.

The Herpes simplex virus is a widespread virus that often causes cold sores, and most people carry it. By removing a virulence gene, i.e. a gene that makes the virus harmful to humans, the herpes virus can be repurposed as a cancer vaccine. This modification prevents the virus from harming healthy tissue while allowing it to target cancer cells, which function differently from normal cells. These findings are presented in a new doctoral thesis at Åbo Akademi University, Finland.

Aging brain shows deterioration of blood-brain barrier (BBB), but the underlying mechanisms are unclear. Guo et al, from Massachusetts General Hospital, reported that the effects of astrocytes on endothelial cell permeability depend on the “age” of astrocytes, and increased angiotensinogen expression in senescent astrocytes may be one of the mediators. These data suggest the importance of cell-cell interaction in neurovascular unit, and point towards a potential therapeutic approach to rescue BBB in aging brain.

Immune cells called double negative T cells are abundant in the intestine but have been poorly understood till date. In a recent study, researchers from Institute of Science Tokyo report that these cells actually have an indispensable role in suppressing intestinal inflammation. Through cutting-edge microscopy that allows live imaging, the movement and functioning of these cells were visualized for the first time, providing insights into conditions such as Crohn’s disease.