Michael Koob, PhD, and his team from University of Minnesota Medical School have been selected to join the Collaborative Research Network (CRN)External link that opens in the same window, an international, multidisciplinary, multi-institutional network working to address high-priority research questions about Parkinson's disease, through a $6 million grant awarded by Aligning Science Across Parkinson’s (ASAP)External link that opens in the same window, in partnership with The Michael J. Fox Foundation for Parkinson’s Research (MJFF)External link that opens in the same window. 

A new preclinical study led by researchers at The University of Texas MD Anderson Cancer Center and Weill Cornell Medicine has uncovered genetic and cell-state adaptive mechanisms that drive resistance to KRAS inhibitors in patients with KRAS-mutant colorectal cancer. These findings suggest that targeting early inflammatory responses by adding TBK1 blockade with KRAS inhibition may be a promising combination strategy to overcome treatment resistance.

Physicians at the Icahn School of Medicine at Mount Sinai are calling for updates to a widely used system that grades side effects from cancer treatments, warning that current criteria may misclassify the severity of skin-related toxicities and limit consistency across clinical trials.

In exploring how serotonin affects how people learn and adapt to changes, researchers found that the neurotransmitter helps reduce "belief stickiness" — the tendency to get stuck on an old idea despite new contradicting evidence. According to the researchers, the discovery, detailed in Nature Mental Health, holds important implications for the understanding and treatment of obsessive-compulsive disorder (OCD). 

An overabundance of a common DNA repair protein can mimic the effects of a mutation in the BRCA gene — a genetic flaw linked to hereditary breast and ovarian cancer — even in tumors that test negative for it, according to a new study led by Penn State College of Medicine researchers. The finding raises the possibility of more personalized cancer treatment for patients whose tumors don't carry the genetic mutations doctors typically screen for.

As temperatures rise across the UK, new research from the University of East London warns that overheating in homes, hospitals and care settings is becoming a major public health threat, with older people and vulnerable groups most at risk. The study finds that current building regulations and heat adaptation measures are failing to keep pace with climate pressures, leaving millions exposed to unsafe indoor temperatures. Researchers are calling for stronger overheating rules, better public guidance and greater integration of heat resilience into housing, healthcare and planning policy.

Scientists at the Icahn School of Medicine at Mount Sinai have created a new artificial intelligence (AI) model that helps reveal how genes function together inside human cells, offering a powerful new way to understand biology and disease. The study, published in the May 21 online issue of Patterns, a Cell Press Journal [DOI: https://doi.org/10.1016/j.patter.2026.101565], introduces a gene set foundation model (GSFM) designed to learn patterns in how genes are grouped and function across thousands of biological contexts. The work draws inspiration from advances in large language models (LLMs) such as ChatGPT, which learn how words gain meaning depending on their context. In a similar way, a GSFM learns how genes behave differently depending on their cellular “context.”

About The Study: The findings of this cohort study underscore a gap between evidence and practice. Two-thirds of patients with newly identified heart failure with reduced ejection fraction did not undergo left ventricular ejection fraction reassessment, limiting opportunities to confirm persistence, evaluate reverse remodeling, and identify candidates for treatment. Receipt of guideline-directed medical therapy was modest across groups, even among patients with persistent heart failure with reduced ejection fraction, who derive the greatest benefit.