McGill University researchers have identified a brain function that helps explain why childhood stress raises metabolic health risks for some women later in life.

A new study found that variations in the brain’s insulin receptor network affect how women respond to early-life adversity. This effect has a lesser impact in men, suggesting there is a sex-specific process at play.

Preclinical studies of the serotonin 2A (5-HT2A) antagonist deramciclane suggested an anxiolytic profile, which has not been unequivocally established in the clinic. The same receptor profile also indicated that the compound may exhibit antidepressant potential. However, evidence for these effects remains inconclusive. The present study examined the effect of the drug in two preclinical tests with predictive validity for antidepressant activity.

Scientists unlock the mechanism behind C. diff’s most harmful toxin, opening the door to more targeted treatments that protect gut health and prevent disease recurrence. 

The discharge and prevalence of psychoactive drugs in surface waters has raised concerns about potential risks to ecosystems and public health. Yet there is limited information on the ecotoxicity of these compounds in marine environments and aquaculture.