About The Study: There was no significant difference in sustained return of spontaneous circulation between sodium bicarbonate and placebo in adults with in-hospital cardiac arrest. These findings do not support routine administration of sodium bicarbonate for patients with in-hospital cardiac arrest.
Corresponding Author: To contact the corresponding author, Lars Wiuff Andersen, MD, MPH, PhD, DMSc, email lwandersen@clin.au.dk.
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(doi:10.1001/jama.2026.10628)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Media advisory: This study is being presented at the Critical Care Reviews Meeting 2026.
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Journal
JAMA