Phase 2 TRANQUILITY trial results presented by Mount Sinai investigator support further evaluation of pacibekitug in cardiovascular disease

**Note this is an early release from the Annual Meeting of the European Association for the Study of Diabetes [EASD]. Please credit the meeting when using this research**

New research to be presented at the Annual Meeting of The European Association for the Study of Diabetes (EASD) in Milan, Italy (Sept 28 – Oct 2) estimates the number of people living with type 1 diabetes (T1D) worldwide will increase by 29% from 9.4 million in 2025 to 12.1 million in 2049. In addition, it is estimated that the number of new cases per year will increase by 14% across this same period. The development of these estimates, using the DIAMOND-T1D model, has been led by Professor Anders Green, Steno Diabetes Center Odense, Denmark.

Atlantic herring travel in massive schools that can contain hundreds of millions — and sometimes even billions — of fish. While this abundance is characteristic for one of the most successful vertebrates on Earth, it also creates ideal conditions for viruses, bacteria and parasites to spread.

Now, an international team of researchers led by the Texas A&M College of Veterinary Medicine and Biomedical Sciences (VMBS) has discovered that Atlantic herring have an extraordinary level of diversity in a group of immune genes that help recognize invading pathogens. Published in Science Advances, the study found that the fish’s genetic diversity in these immune genes exceeds what has been reported in any other vertebrate studied so far, including humans.