Cure, the premier healthcare innovation ecosystem, is launching the Cure Innovation Index, the first data-driven framework to measure how effectively U.S. biomedical institutions translate scientific discovery into real-world healthcare solutions and treatments. The Index sets a new standard for measuring translational performance based on the full set of factors required to move innovation from discovery to early research to clinical and commercial impact. The Index ranks the top 303 U.S. academic institutions, selected from more than 6,000 nationwide, and provides benchmarked comparisons and customized improvement recommendations, making translational performance visible, comparable, and actionable. 

Zoonotic diseases continue to present health, social, and economic challenges in China. While the country has demonstrated strong outbreak response capabilities, current efforts remain reactive and top-down. Shifting toward primary prevention at the human–animal–environment interface with enhanced risk communication offers a more sustainable approach to reducing zoonotic disease risks. This review synthesized peer-reviewed and gray literature in English and Chinese to characterize human–animal contact behaviors associated with 93 zoonotic diseases monitored by China’s public health, agricultural, and forestry sectors. It examined contact pathways across key animal groups known to carry zoonotic pathogens, identified human populations at risk, and analyzed the demographic, socio-cultural, and ecological factors shaping these contacts. Focusing on four major human–animal interfaces, the review further identified lessons and best practices for effective risk communications. Findings reveal that human–animal contact in China is diverse and embedded in daily routines, cultural practices, and economic activities, with distinct risk profiles presented across animal groups and socio-ecological settings. Populations such as smallholder farmers, herders, rural residents, market vendors, and workers in informal sectors face higher exposure risk, influenced by socio-economic conditions and ecological changes. Gaps remain in surveillance of informal practices, emerging pathogens, and behavioral data. Evidence from global and local experiences highlights the value of behavior-centered, community-engaged communication grounded in One Health principles, emphasizing participatory design, culturally relevant education, local leadership, and integration with public service systems. Overall, this review provides an integrated understanding of zoonotic disease risks and prevention opportunities from social-behavioral and communication perspectives. It identified priority populations, settings, and best practices for targeted and effective strategies, underscoring the need for coordinated One Health efforts to address complex human–animal–environment interactions and promote proactive zoonotic disease prevention in China and beyond.

Background

Ticks are key vectors of zoonotic diseases in the Northern Hemisphere, including China, yet surveillance and public awareness remain limited. While global studies address risk perception, similar research in China, especially with spatial or longitudinal detail, is scarce. This study assesses tick-borne disease risk perception, influencing factors, and spatial variation in Northeast China and Nei Mongol Zizhiqu (also known as Inner Mongolia Autonomous Region) to inform targeted interventions.

Methods

In 2019, a cross-sectional questionnaire surveyed 4000 adults in Heilongjiang, Jilin, Liaoning, and Nei Mongol Zizhiqu using multi-stage sampling. Knowledge was assessed in four domains: tick biology/ecology, bite treatment, tick-borne diseases, and bite prevention, alongside socio-demographic and behavioral data. Descriptive statistics and multiple logistic regression identified knowledge levels and associated factors.

Results

Knowledge of tick biology was relatively high (1830/4000, 45.8% with high knowledge), but awareness of bite treatment, diseases, and especially prevention was low (31.5% with high tick-borne disease knowledge; 21.6% with high prevention knowledge), even among high-risk groups. Urban residents had higher knowledge than those in rural or remote areas. Frequent woodland visits and prior tick bites increased knowledge of tick biology (regression coefficients: 0.311 and 0.387, both P < 0.001) but not prevention. Education and outdoor activity showed mixed associations with knowledge domains.

Conclusion

Major gaps exist in public knowledge of tick-borne diseases, particularly regarding prevention, with notable disparities across regions and risk groups. Targeted, region-specific interventions are urgently needed to improve awareness and protection, especially in high-risk and low-awareness areas.

The decline in marriage and fertility rates has emerged as a prominent demographic trend in recent decades, with women’s education being identified as a critical factor. In an insightful study, researchers investigated the causal relationship between women’s education and family formation in Japan and found that education only modestly delays family formation. These findings suggest that other institutional factors deserve greater attention in understanding the demographic trends in East Asia.