For the first time, researchers have experimentally discovered optical meron-antimeron pairs—a novel class of topological quasiparticles that were originally conceived in particle physics and later found in magnets, but had never been realized in optics. By employing group representation theory, the team not only generated these states in deep-subwavelength plasmonic systems but also established a complete symmetry classification that dictates their topological invariants. This framework reveals a fundamental chirality-parity locking effect and enables the creation of isolated merons. Harnessing the robustness of these symmetry-protected states, the work demonstrates an ultra-sensitive sensing application with a record λ/133 resolution, bridging abstract theory to practical photonic technology.

A research team led by Professor Xiang David Li from the Department of Chemistry at The University of Hong Kong (HKU), in collaboration with researchers from the Shenzhen Bay Laboratory and Tsinghua University, has made a breakthrough in epigenetic drug discovery. The team has successfully developed a first-in-class chemical inhibitor that precisely and selectively targets the ATAC complex, a critical cellular “switch operator” that activates tumour-promoting genes, opening a novel therapeutic avenue for non-small cell lung cancer (NSCLC). The findings were recently published in the top-tier journal Nature Chemical Biology, and multiple international patent applications have been filed.

POSTECH, the University of Wisconsin–Madison, and the University of Tokyo control oxide electronic structures via local atomic arrangements at moiré interfaces.

Seeing chemistry unfold inside living cells is one of the biggest challenges of modern bioimaging. Raman microscopy offers a powerful way to meet this challenge by reading the unique vibrational “signatures” of molecules. However, cells are extraordinarily complex environments filled with thousands of biomolecules. To make specific molecules stand out, researchers often attach small chemical “probes,” such as alkyne tags, that produce signals in a so-called cell-silent spectral window where native cellular components do not scatter light. This allows Raman microscopes to selectively detect the tagged molecules against an otherwise crowded molecular background. Despite this advantage, the widespread adoption of Raman microscopy in biology has been limited by one fundamental problem: Raman signals are extremely weak. In a new study published in Angewandte Chemie International Edition, TIFR researchers report a molecular design strategy that dramatically amplifies Raman signals, enabling the development of Raman sensors that can detect biomolecules using standard spontaneous Raman microscopes. These new Raman sensors enable sensitive, ratiometric imaging of biological molecules and ions, such as hydrogen peroxide molecules, copper ions, and pH, inside living cells. The work is supported by the Department of Atomic Energy, Government of India, and the Japan Science and Technology Agency, with the research team comprising Prof. Ankona Datta and Sujit Das from the Tata Institute of Fundamental Research, Mumbai, and Heqi Xi, Itsuki Yamamoto, and Prof. Katsumasa Fujita from the University of Osaka, Japan.

Antibiotics that save lives can also become hidden environmental threats once they leave hospitals and households. A new study reports an innovative solution that transforms sewage waste into a low cost, eco friendly sensor capable of detecting trace levels of the widely used antibiotic trimethoprim in water, urine, and pharmaceutical samples.

Pilot whale samples from 1986-2023 show that legacy PFAS are declining in the open ocean. Newer PFAS remain a major unknown and may be accumulating in near-source environments.

Professor Hirotoshi Mori (Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University), together with Nichika Ozawa (first-year Ph.D. student at Ochanomizu University) and Assistant Professor Nahoko Kuroki of Ochanomizu University, has proposed a new design principle for QM/MM (quantum mechanics/molecular mechanics) simulations. The approach enables objective and automatic determination of the quantum-mechanical region based on electronic-state changes, addressing a long-standing challenge in multiscale molecular simulations. This work was published online in Advanced Science on December 23, 2025 (JST), an international journal that features conceptually innovative and interdisciplinary breakthroughs across materials science, life science, chemistry, and physics. This article will be published in issue 17 (March 23rd) of Advanced Science, and the cover design suggestion has been selected to be featured on a frontispiece in it. A frontispiece is a full-page image (similar to a cover) placed at the beginning of this article that highlights outstanding results.