23-Jul-2026
Chitosan hydrogel stabilizes red blood cell membrane interfaces for advanced environmental sensing
Journal of Bioresources and BioproductsPeer-Reviewed Publication
The development of stable biomimetic interfaces remains challenging because natural cell membranes often lose structural integrity and biological activity when incorporated into artificial sensing systems. In a recent study published in the Journal of Bioresources and Bioproducts, researchers developed a chitosan hydrogel-stabilized red blood cell membrane (RBCM) interface for robust electrochemical detection of environmental contaminants. The chitosan-derived conductive hydrogel served as a multifunctional matrix, using its three-dimensional polycationic network and abundant amino groups to electrostatically anchor RBCMs while preserving membrane fluidity and acetylcholinesterase activity. The incorporation of carboxylated multi-walled carbon nanotubes further improved electron transfer efficiency without compromising biocompatibility. The resulting biomimetic interface retained 85.8% of its initial electrochemical response after seven days of continuous operation and enabled sensitive detection of organophosphate pesticides in real agricultural samples, including apples, oranges, and tomatoes. The study demonstrates the potential of natural polysaccharide-based materials as versatile platforms for constructing stable biomembrane composites in environmental sensing.
- Journal
- Journal of Bioresources and Bioproducts