Salk scientists identify two cellular programs linked to age-related dysfunction, ferroptosis and senescence, are mechanistically linked through the enzyme acid ceramidase. The team finds that senescent “zombie” cells are more vulnerable to regulated cell death through ferroptosis and that they can pass that sensitivity on to neighboring cells. The observations suggest acid ceramidase could be a powerful therapeutic target for supporting healthy aging and preventing age-related diseases and disorders such as arthritis, dementia, and cancer.

Reliable defect detection is critical for the safe operation of heavy-haul railways. However, ultrasonic inspection signals are often distorted by complex non-Gaussian noise in small-radius curve sections. A research team developed a physics-informed denoising framework that integrates multi-feature fusion within an ideal binary mask paradigm. The proposed method improves defect echo extraction accuracy and reduces the risk of missed detections.

Revolver Therapeutics has won the health category of the Royal Society of Chemistry's Emerging Technologies Competition 2026.