Beyond Matrigel: A novel hydrogel system designed to facilitate the transplantation of hPSC-derived cells and tissue
Peer-Reviewed Publication
Updates every hour. Last Updated: 13-May-2026 07:15 ET (13-May-2026 11:15 GMT/UTC)
Researchers from the University of Cambridge, the National University of Singapore, and A*STAR (Singapore) have developed a clinically defined and translatable hydrogel system using physiological proteins. A base hydrogel, termed “Alphagel”, supported the culture and trilineage differentiation of human pluripotent stem cells (hPSCs) in a three-dimensional environment and demonstrated biocompatibility in vivo. They then engineered a liver-optimised hydrogel, “Hepatogel”, which was shown to improve the retention of hPSC-derived hepatocytes upon direct transplantation into murine livers.
Researchers at the National University of Singapore (NUS) have identified a protein called tyrosine phosphatase 1B (PTP1B) as a potential “switch” that can modulate a type of cancer cell death known as immunogenic cell death (ICD). A research team led by Professor ANG Wee Han from the NUS Department of Chemistry has discovered two platinum-containing compounds, namely Pt-NHC and PlatinER (Pt-ER) that can trigger ICD. In their research model study, tumour cells treated with these compounds were effective in helping to develop immunity protection against colorectal cancer. This work was carried out in collaboration with Associate Professor Maria BABAK from the City University of Hong Kong.
A joint research team from POSTECH and Ewha Womans University develops a spray-type coating that adheres to transplant organs and prevents immune rejection.