Research groups of Professors Weiqi Zhang, Haiyan Xu and Lin Wang from the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, reported a positively-charged dextran nano-photosensitizer (p-Dex PS) facilitates tumor-associated macrophage (TAM)-mediated delivery and sublethal light-induced metabolic reprogramming, which boosts the TAM polarization and subsequently the anticancer immune effects.

While unitized regenerative fuel cells (URFCs) are promising for renewable energy storage, their efficient operation requires simultaneous water management and gas transport, which is challenging from the standpoint of water management. Herein, a novel approach is introduced for examining the alignment hydrophilic pattern of a Ti porous transport layer (PTL) with the flow field of a bipolar plate (BP). UV/ozone patterning and is employed to impart amphiphilic characteristics to the hydrophobic silanized Ti PTL, enabling low-cost and scalable fabrication. The hydrophilic pattern and its alignment with the BP are comprehensively analyzed using electrochemical methods and computational simulations. Notably, the serpentine-patterned (SP) Ti PTL, wherein the hydrophilic channel is directly aligned with the serpentine flow field of the BP, effectively enhances oxygen removal in the water electrolyzer (WE) mode and mitigates water flooding in the fuel cell (FC) mode, ensuring uninterrupted water and gas flow. Further, URFCs with SP configuration exhibit remarkable performance in the WE and FC modes, achieving a significantly improved round-trip efficiency of 25.7% at 2 A cm⁻².

Researchers have developed DrugtargetMR, a comprehensive computational tool designed to bridge the gap between genetic discoveries and clinical applications. By integrating multi-omics data with advanced statistical modeling in a unified R framework, the software simplifies the identification of causal genes and therapeutic targets for complex human traits, making sophisticated post-GWAS analysis accessible to the broader scientific community.

Proton exchange membrane fuel cells (PEMFCs) have attracted significant attention as sustainable energy technologies due to their efficient energy conversion and fuel flexibility. However, several challenges remain, such as low catalytic activity of fuel cell membrane electrode assembly (MEA), insufficient mass transfer performance, and performance degradation caused by catalyst deactivation over long period of operation. These issues are especially significant at high current densities, limiting both efficiency and operational lifespan. Mesoporous carbon materials, characterized by a high specific surface area, tunable pore structure, and excellent electrical conductivity, are emerging as crucial components for enhancing power density, mass transfer efficiency, and durability of PEMFCs. This review first discusses the properties and advantages of mesoporous carbon and outlines various synthetic strategies, including hard template, soft template, and template-free approaches. It then comprehensively examines the applications of mesoporous carbon in PEMFCs, focusing on their effects on the catalyst and gas diffusion layer. Finally, it concludes with future perspectives, emphasizing the need for further research to fully exploit the potential of mesoporous carbon in PEMFCs.

Increased extracellular matrix (ECM) stiffness, a hallmark of risk in cardiovascular disease (CVD), is closely associated with inflammation triggered by immune cell infiltration in the vessel wall.

With the rapid revolution in super-resolution microscopy, the resolution of far-field optical microscopy has entered the sub-nanometer era, providing new insights into macromolecules in vitro and in situ.

The intricate structure of the brain at various scales is linked to its functional and biomechanical properties. Since understanding the biomechanical properties is vital for comprehending brain diseases, development, and injuries, measurements at different scales are necessary.