α-Synuclein (α-Syn) is a presynaptic protein primarily associated with Parkinson’s disease and other neurodegenerative diseases.

ATP-sensitive potassium (K_ATP) channels are integral components in excitable cells, particularly in cardiomyocytes, serving as critical regulators of cellular metabolism and electrical excitability.

A Canadian team turned 23,000 mating types into a materials library, showing nuclear-mitochondrial combos double film strength or ductility depending on cross-linker choice.

Writing in the Journal of Bioresources and Bioproducts, researchers report the first systematic screen of wild fungal genotypes for pure mycelial materials, proving that strain choice can outperform process tweaks in green fabrication.

Engineers have merged neomycin-grafted cellulose nonwovens with a polyvinyl-alcohol/cellulose-nanofiber aerogel to create a biodegradable smart bandage that delivers >99 % kill of Staphylococcus aureus and Escherichia coli within 30 min, scavenges 93 % of free radicals and produces –1.4 mmHg micro-negative pressure to pull exudate away from chronic lesions. Reporting in the Journal of Bioresources and Bioproducts (2025, 10, 373-385) the team show that blueberry-derived anthocyanins embedded in the matrix act as a built-in pH sensor, shifting colour when infection drives wound alkalinity above pH 8. In a murine full-thickness infection model the dressing closed 88 % of wound area in seven days, outperforming a leading commercial dressing and suppressing inflammatory IL-1β and TNF-α expression to baseline levels. Complete soil burial disintegrates the device within 90 days, offering a plastic-free route to connected wound care.

This study uncovers a new molecular mechanism by which the E3 ubiquitin ligase PIAS4 orchestrates pluripotency exit and lineage commitment in porcine embryonic stem cells (pESCs). Using a genome-wide CRISPR screening approach, the researchers identified PIAS4 as a critical regulator that modulates histone H3K4me3 marks via SUMOylation-mediated stabilization of KDM5B. Loss of PIAS4 impaired stem cell differentiation, disrupted lineage specific gene programs, and altered mesendoderm specification through LEFTY2–SMAD signaling. These findings not only provide fundamental insight into porcine stem cell biology but also pave the way for applications in livestock breeding, artificial meat production, and regenerative medicine.

To address this challenge, Professor Liu Rui's team from South China University of Technology introduces a novel quantitative method, cell-specific causal network entropy (CCNE), which analyzes gene-level causal relationships to infer distinct causal networks for individual cells and identify pre-transition states in complex biological systems.

Researchers at Texas A&M University model extreme conditions using 3D bioprinting, revealing insights that could make flight and space travel protocols safer while driving new breakthroughs in respiratory disease research and drug discoveries.