Candida auris is a rising global health threat due to multidrug resistance, emphasizing the urgent need for novel antifungal strategies. The C. auris glycosylphosphatidylinositol transamidase (GPI-T) complex is the key enzyme that mediates the attachment of GPI anchors to target proteins.

Researchers have identified a critical genetic pathway involving the protein FOXO1 that maintains the health of the epididymis, a vital component of the male reproductive system. The study reveals that the age-related decline of this pathway drives cellular senescence and infertility. Furthermore, experimental treatments using specialized stem cells demonstrated the ability to restore this pathway, offering a promising new strategy for preserving male reproductive longevity.

The gold standard for treating a heart attack—rapidly restoring blood flow—comes with a deadly catch. This sudden reoxygenation often triggers a secondary wave of tissue destruction known as ischemia/reperfusion injury. Now, a study published in Protein & Cell unveils a revolutionary strategy to neutralize this "reperfusion shock" using a recombinant protein called human MG53 (rhMG53).

Childhood adversity has been linked to many types of diseases; however, the underlying biological mechanisms remain inadequately explored, hindering the development of preventive programs and targeted interventions. The plasma proteome has become a promising tool for investigating the mechanisms underlying disease development in recent years. What are the plasma proteomic signatures of childhood adversity, and how do they contribute to the associations of childhood adversity with diseases?

An integrative review led by the Afrifa-Yamoah research team and co-authored by scholars from Canada, Australia and other countries has been published in Eye & ENT Research. Against the backdrop of the global myopia epidemic, this paper systematically elaborates the genetic, optical and environmental mechanisms driving the onset and progression of myopia, and analyzes the underlying principles of relevant risk factors. It also classifies mainstream myopia correction and control measures, summarizes their clinical effects, and puts forward clinical strategies for personalized and combined interventions. This study provides comprehensive and authoritative theoretical references for clinical ophthalmology practice, myopia prevention and control, as well as future research.

This report presents the first documented case of an extraosseous Ewing’s sarcoma (ES) arising primarily in the retropharyngeal space of an adult. A 59-year-old female presented with progressive dysphagia and acute stridor, initially mimicking a retropharyngeal abscess. However, intraoperative findings showed no pus, and further immunohistochemistry and genetic testing confirmed ES with CD99 positivity and EWSR1 rearrangement. Despite multimodal considerations, the disease was extensive at diagnosis, and the patient deteriorated rapidly, passing away within two months.

A recent case report from Mayo Clinic in Eye & ENT Research documents the first-ever case of vocal fold paralysis (VFP) following Z-POEM. A 68-year-old male developed hoarseness one day after the procedure, and laryngoscopy later confirmed left VFP. This finding breaks the prior safety record of Z-POEM and highlights the vulnerability of the recurrent laryngeal nerve, which lies close to the diverticulum base and is at risk during septal division. This article presents the case from anatomical, diagnostic, and management perspectives, offering a critical safety reference for clinicians performing Z-POEM.