A phase 2 clinical trial showed burosumab, a targeted antibody therapy, safely restored phosphate balance in children and adults with fibrous dysplasia, a rare bone disorder associated with fractures and deformities. The therapy reduced abnormal bone turnover markers and improved mobility in severely affected children, including independent walking after full-time wheelchair use. The findings suggest that inhibition of fibroblast growth factor-23 may help reduce disability and improve physical function in patients with phosphate-wasting skeletal disease.

Achieving in situ dynamic tracking of neurotransmitters in the complex intestinal lumen remains a major technical challenge in gastroenterology and biosensing. The research team developed a general sensing architecture that integrates a one-dimensional nanoconductive network with supramolecular host-guest recognition, and on this basis constructed a stretchable electrochemical sensing platform. This platform offers a systematic solution to three key obstacles in the in situ detection of small molecules in the gut lumen: adaptation to mechanical deformation, suppression of biofouling, and selective recognition of structurally similar molecules. Using this framework, the team revealed for the first time the central role of enterochromaffin cells (ECs) in immune-mechanical signal integration by electrochemical strategy. Under stimulation by microbial mimetics and their metabolites, ECs integrate multiple external signals and reset their response threshold through dual regulation: enhancing neurotransmitter synthesis and storage while increasing sensitivity to mechanical stimulation.

The significance of this study lies not only in validating sensing performance in the intestinal setting, but also in proposing a practical strategy to address a long-standing and widely shared challenge in in vivo electrochemical monitoring. More importantly, by emphasizing the coordinated design of sensing material structure and function, this work moves beyond optimizing a single performance metric in stretchable devices and instead establishes a systematic framework for accurate chemical information acquisition in complex mechanical and biochemical environments. Although the intestinal lumen serves here as a particularly challenging validation scenario, the underlying design principles are expected to be applicable to other in vivo monitoring systems.

Researchers have successfully engineered an L-amino acid deaminase to overcome substrate inhibition, a major bottleneck in the biocatalytic production of phenylpyruvic acid. The study demonstrates an approximately 17-fold improvement in productivity at high substrate concentrations through strategic modification of the enzyme’s binding pocket.

New research from Singapore University of Technology and Design and the Singapore-ETH Centre finds that private cooling may protect people from heat while reducing the perceived urgency of broader urban climate solutions — a pattern the researchers call “behavioural insulation”.

Researchers have created an innovative paper-based analytical device that can detect microRNA-21—a biomarker associated with multiple cancers—using only a smartphone camera for readout, demonstrating a cost-effective platform with potential for point-of-care cancer diagnostics.

This study establishes a general design platform for narrowband emitters via precise control over molecular skeletal engineering. By directing π‑electron reorganization, aromaticity is rationally tuned from global delocalization to discrete local localization, which restricts long‑range π‑electron delocalization, suppresses vibrational coupling in the excited state, and diminishes vibronic shoulder features, thereby enabling intrinsically narrowband emission. OLED devices incorporating representative emitter achieve both exceptional color purity and high electroluminescence efficiency, with CIE coordinates that closely match the BT.2020 standard for red emission.

A highly efficient immobilized cell system for continuous production of cadaverine, a key building block for polyamide synthesis was successfully developed, which demonstrated a 19-fold improvement in catalyst productivity compared to free cells, achieving stable operation for 200 hours in a packed-bed reactor.

A code-reuse attack named “Segmentation Fault Oriented Programming (SFOP)” exploits weaknesses in signal handling and Intel CET in Linux systems. SFOP is capable of bypassing Intel CET in any program by producing segmentation faults in sequence. The program under attack is first made to access a restricted area of memory and then repeatedly crashed by executing invalid instructions. Every time it receives a SIGSEGV signal in return, the attacker registers a signal handler that succeeds in crashing the program. Registering a different piece of code every time, the attacker advances step by step, achieving arbitrary code execution. SFOP is enabled by 12 priorly unknown weaknesses that affect Linux signals. It has been discovered by Marcos Bajo, Apostolos Chatzianagnostou, and Christian Rossow at the CISPA Helmholtz Center for Information Security, together with Ritvik Goyal at the Indian Institute of Technology Kanpur. 

A new review maps out how polymer-based electrodes could help solve persistent safety, stability, and sustainability problems in solid-state metal-ion batteries. Unlike conventional designs that rely on flammable liquid electrolytes and rigid inorganic materials, polymer electrodes offer mechanical flexibility, chemical tunability, and superior interfacial contact. The analysis synthesizes recent advances in conducting and redox-active polymers, highlighting their potential to enable all-organic solid-state batteries that are lightweight, intrinsically safe, and compatible with low-energy manufacturing. The authors also identify key design strategies—including molecular engineering, composite formation, and interface modification—that could accelerate the transition from laboratory prototypes toward practical, scalable energy storage devices.