Open problems: Cracking cell complexity with collective intelligence
Peer-Reviewed Publication
Updates every hour. Last Updated: 13-Nov-2025 00:11 ET (13-Nov-2025 05:11 GMT/UTC)
Researchers from more than 50 international institutions have launched Open Problems (https://openproblems.bio), a collaborative open-source platform to benchmark, improve, and run competitions for computational methods in single-cell genomics. Co-led by Helmholtz Munich and Yale University, the initiative aims to standardize evaluations, foster reproducibility, and accelerate progress towards open challenges in this fast-moving field.
Joint health is critical for musculoskeletal (MSK) conditions that are affecting approximately one-third of the global population. Monitoring of joint torque can offer an important pathway for the evaluation of joint health and guided intervention. However, there is no technology that can provide the precision, effectiveness, low-resource setting, and long-term wearability to simultaneously achieve both rapid and accurate joint torque measurement to enable risk assessment of joint injury and long-term monitoring of joint rehabilitation in wider environments. Herein, we propose a piezoelectric boron nitride nanotubes (BNNTs)-based, AI-enabled wearable device for regular monitoring of joint torque. We first adopted an iterative inverse design to fabricate the wearable materials with a Poisson’s ratio precisely matched to knee biomechanics. A highly sensitive piezoelectric film was constructed based on BNNTs and polydimethylsiloxane and applied to precisely capture the knee motion, while concurrently realizing self-sufficient energy harvesting. With the help of a lightweight on-device artificial neural network, the proposed wearable device was capable of accurately extracting targeted signals from the complex piezoelectric outputs and then effectively mapping these signals to their corresponding physical characteristics, including torque, angle, and loading. A real-time platform was constructed to demonstrate the capability of fine real-time torque estimation. This work offers a relatively low-cost wearable solution for effective, regular joint torque monitoring that can be made accessible to diverse populations in countries and regions with heterogeneous development levels, potentially producing wide-reaching global implications for joint health, MSK conditions, ageing, rehabilitation, personal health, and beyond.
Chihtong “Lily” Lee never set out to reinvent surgical tools, but her curiosity, precision and creativity led her to do just that. The 2025 Rice University graduate recently earned second place in the undergraduate category at the ASME SB3C Summer Bioengineering Conference, a competition hosted by the American Society of Mechanical Engineers.
A recent study investigates the contrasting patterns of symbiotic nitrogen fixation (SNF) and asymbiotic nitrogen fixation (ANF) along altitudinal gradients in subtropical forests. The research found that SNF rates declined with increasing altitude due to higher soil nitrogen availability and lower air temperatures, while ANF rates showed a hump-shaped pattern, influenced by soil properties at lower altitudes and climatic factors at higher altitudes. The study underscores the importance of distinguishing between SNF and ANF in ecological studies and Earth system models, providing valuable insights for improving global BNF estimates and refining model predictions.