A new study identifies CMPK2 as a key driver of hepatic ischemia‑reperfusion injury (HIRI) by triggering mitochondrial redox imbalance, free fatty acid overload, and mtDNA‑driven sterile inflammation. The natural compound acteoside (ACT) directly targets CMPK2, blocks IRF1‑driven transcription, promotes mitophagic degradation of CMPK2, and interrupts the vicious inflammatory cycle, offering a safe and translatable protective strategy for liver surgery and transplantation.

The Ti₃C₂T_x/Bi₂Se₃ hybrid was constructed to explore a thermal protection strategy in infrared imaging via its enhanced photothermal conversion, providing a promising strategy for developing advanced photothermal materials in stealth technologies.

A research team led by Professor Jianwu Dai from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, in collaboration with Professor Rui Gu’s team from the China-Japan Union Hospital of Jilin University and Professor Yi Cui from the National Research Institute for Family Planning, has developed a novel therapeutic paradigm for spinal cord injury repair. By integrating the physical signaling regulation of traditional Chinese electroacupuncture with modern tissue engineering regenerative strategies, this study establishes a new treatment model that integrates complementary strategies from Eastern and Western medical practices.

Atoms and molecules are the fundamental building blocks of matter. Spectroscopy identifies and quantifies chemical species through the unique spectral fingerprints they imprint on light. Spectroscopy has many applications, ranging from fundamental tests of quantum electrodynamics and investigations of molecular structure to environmental sensing, biomedical diagnostics and industrial monitoring. A highly promising spectroscopic instrument that has the potential to transform the field has emerged over the years: the dual-comb spectrometer. This relies on the interference of two mode-locked ultrafast lasers that produce broad frequency combs composed of evenly spaced narrow spectral lines. In a tutorial article published in Nature Reviews Methods Primers, Nathalie Picqué and Theodor W. Hänsch review the principles, advances and future opportunities of the rapidly developing field of broadband atomic and molecular science using dual-comb spectroscopy.

An electron-donor/electron-acceptor (EDG/EWG) ratio-guided molecular engineering strategy is established to optimize the buried interface of n-i-p perovskite solar cells (PSCs). The EDG-rich dipolar molecule L-2,4-diaminobutyric acid (DBA) delivers superior passivation effects, enabling high power conversion efficiency together with good stability. This work identifies that passivating the perovskite side is more critical than the electron selective layer (ESL) side for achieving high-performance PSCs.

UC San Diego engineers created a soft, wearable ultrasound patch that can continuously monitor a fetus for hours at a time, even during constant movement. The technology could help doctors detect complications earlier in high-risk pregnancies and expand access to prenatal care in low-resource areas.

Researchers at Nanjing University developed platinum(IV)-antibody conjugates that enhance tumor immunogenicity without relying on strong cancer cell killing. The targeted system delivers low-dose platinum selectively to tumors, increasing MHC-I expression and improving immune recognition while reducing systemic toxicity. In mouse models, the strategy significantly enhanced the efficacy of anti-PD-1 immunotherapy.