New framework renders AI trustworthy for cancer subtyping
Peer-Reviewed Publication
Updates every hour. Last Updated: 30-Oct-2026 20:15 ET (31-Oct-2026 00:15 GMT/UTC)
Reported June 23 in Nature Biomedical Engineering, researchers at Vanderbilt Health and centers in Hong Kong have created a versatile uncertainty-aware AI framework broadly adaptable as a wrapper for digital pathology AI systems. (An AI wrapper acts as an interface layer that customizes, formats and automates how users interact with the underlying intelligence.) They demonstrate their wrapper, called TRUECAM, primarily with reference to non-small cell lung cancer (NSCLC) subtyping using whole-slide images.
UCLA scientists are calling for a large-scale initiative to understand how human cells influence one another — a missing layer of biology that could reveal how cellular interactions drive disease and inform new therapies.
Nanyang Technological University, Singapore (NTU Singapore) scientists have used a classic optical phenomenon known as the “Poisson spot” to create stable patterns of light called “optical skyrmions”. Optical skyrmions are tiny, swirling configurations in the properties of light – akin to the spikes of a hedgehog. The team used a laser directed at a small circular disc, instead of the complex and costly engineered materials commonly used to generate these skyrmions. This new method gives scientists a much simpler way to generate, study and adjust optical skyrmions.
Skyrmions are currently a hot scientific subject as they hold potential to store information, paving the way for future data storage, communications and computing systems. Published in a leading scientific journal, Optica, the discovery was led by Nanyang Assistant Professor Shen Yijie from NTU’s School of Physical and Mathematical Sciences and School of Electrical and Electronic Engineering.