Large and complex construction projects (LCCPs) require substantial investments and often encounter significant challenges, such as cost overruns, time delays, and conflicting stakeholder interests. A new study reviews 165 peer-reviewed publications to propose a modernized value management framework tailored for LCCPs, paving the way for improved stakeholder collaboration and technological integration.

CRISPR is a powerful DNA-editing tool that has underpinned huge advancements in human healthcare in the last decade. It is a precision tool, but is not perfect, and misplaced DNA edits can compromise safety and efficacy, costing billions each year. Researchers at the MRC Laboratory of Medical Sciences (LMS), Imperial College London and the University of Sheffield have published research in Nature showing that the physical twisting of DNA plays an important role in these mistakes. Using a newly developed platform of tiny (nanometer-sized) DNA circles, called DNA minicircles, the team captured never-before-seen interactions between CRISPR and DNA, providing insights that could help eradicate errors altogether.

Solid materials for carbon capture can help reduce greenhouse gas emissions, but many existing systems remain energy-intensive and costly, because releasing captured carbon dioxide (CO₂) typically requires high temperatures. Recently, researchers from Japan developed three kinds of 'viciazites', a new type of carbon-based material with precisely positioned nitrogen-containing functional groups. Through tight molecular control, these materials can release captured CO₂ at temperatures as low as 60 °C, paving the way for efficient carbon capture.