In a paper published in National Science Review, the team of Pro. Liu present an innovative computational framework, the sample-perturbed Gaussian graphical model (sPGGM), designed to analyse disease progression and identify pre-disease stages at the specific sample/cell level based on optimal transport theory and Gaussian graphical models. The proposed sPGGM provides a new single-sample way to identify the pre-disease state and discover signaling molecules leading to potential disease, which showcases exceptional effectiveness and robustness for both bulk and single-cell data analyses, offering a novel perspective for personalized disease prediction.

Brain aneurysm is the leading cause of brain hemorrhages. To combat the growing cases of brain aneurysms in China, researchers are conducting a large-scale, national clinical study to evaluate the best surgical and endovascular treatments for unruptured brain aneurysms. The China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA) has enrolled up to 25,000 patients across 83 hospitals and is all set to refine the treatment guidelines for brain aneurysms in Chinese patients.

MONSARAZ, PORTUGAL – 30 June 2025 – The silence was broken by cheers and the snap of camera shutters as nine European high school students stepped out of a simulated Mars environment in Portugal, successfully completing the first-of-its-kind EXPLORE analog mission. From 23 to 27 June 2025, these students from Austria, Greece, and Portugal traded their everyday lives for a challenging five-day immersion in an isolated, Mars-like landscape near Monsaraz, in the wilds of the Alentejo province.

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of RNA-based drugs can significantly enhance their effectiveness. These promising therapeutics are currently used to treat rare genetic diseases.

Pitt School of Medicine and La Jolla Institute for Immunology collaboration reveals an opportunity for developing a therapy against the leading infectious cause of birth defects in the United States.