Hearing impairment may be a sign of increased risk of Parkinson’s disease
Peer-Reviewed Publication
Updates every hour. Last Updated: 11-Jul-2025 01:10 ET (11-Jul-2025 05:10 GMT/UTC)
There may be a link between hearing impairment and an increased risk of developing Parkinson’s according to research led by Lancaster University.
This is one of the first studies to examine whether sensory impairments, such as hearing loss, might increase the risk for Parkinson’s or serve as an early warning sign.
Parkinson's UK reports that an estimated 153,000 people in the UK currently live with Parkinson's, which is the fastest-growing neurological condition in the world.Epigenetic modifiers, enzymes that catalyze covalent modifications on chromatin, play a pivotal role in establishing stable states for gene expression and cellular identity. Mutations in these modifiers have been linked to a variety of human diseases, including developmental disorders and cancers, highlighting the importance of understanding how these mutations impact the functions of epigenetic modifiers in development and disease. Recent findings suggest that some epigenetic modifiers may have noncatalytic functions, independent of their catalytic activities, which raises questions about the determinants of their dependency on catalytic activity and the implications for chromatin modifications. In this context, a comment by Chen et al. provides valuable insights into the catalytic and noncatalytic functions of the histone methyltransferase SETD2, a protein responsible for histone H3 lysine 36 trimethylation (H3K36me3) and frequently mutated in clear cell renal cell carcinoma.
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