Ovarian cancer, a deadly gynecologic malignancy, has seen a significant shift in its treatment paradigm with the introduction of poly (ADP-ribose) polymerase (PARP) inhibitors, which are now standard in the maintenance setting following first-line chemotherapy. This retrospective cohort study investigates the real-world effectiveness and safety of olaparib, a PARP inhibitor, in patients with newly diagnosed advanced-stage, high-grade serous ovarian cancer who are HRD positive but BRCA wild-type, a demographic less extensively explored in previous research. The primary goal was to assess the 1-year progression-free survival (PFS) rate of olaparib maintenance therapy in this specific patient group, offering insights into its potential as a therapeutic option.

A new study published in The BMJ suggests that prehabilitation (also called prehab) may be able to reduce complications and length of hospitalization after surgery, while also improving quality of life and physical recovery. The systematic review and meta-analysis, which is the largest of its kind, examined data from more than 15,000 patients who participated in 186 randomized controlled clinical trials around the world.

There’s a downside to being a powerful alpha male -- at least if you’re a baboon. Studies show that despite their high rank, the No. 1 males in baboon society are also some of the most stressed out, as measured by their high levels of glucocorticoid hormones. But new research reveals it’s not the time they spend fighting with other males that raises their stress. Instead, it’s the effort they put into their mates.