Researchers unlock safer RNA therapies for inflammatory diseases
Peer-Reviewed Publication
Updates every hour. Last Updated: 2-Jan-2026 10:11 ET (2-Jan-2026 15:11 GMT/UTC)
Lipid nanoparticles (LNPs) are tiny fat bubbles that are used to deliver medicines, genes, and RNA into cells. However, in some cases LNPs can cause harmful inflammation as a result of the process of RNA delivery. Now, two new solutions can help alleviate inflammation while still getting RNA where it needs to be in the cell. One discovery found that inflammation could be reduced with the addition of a unique biodegradable lipid to the treatment; another solution identified a common drug, called thiodigalactoside (TG), which blocked inflammation when added to the LNP. Today’s Nature Nanotechnology features this research from the Perelman School of Medicine at the University of Pennsylvania.
A researcher at The University of Texas at Arlington is helping a leading national cancer center explore how wearable devices could help childhood cancer survivors avoid long-term health complications such as diabetes and heart disease. Yue Liao, assistant professor of kinesiology at UT Arlington, was invited by researchers at City of Hope, a National Cancer Institute-designated comprehensive cancer center, to contribute to a review article published in Cancer. The article examines how survivors of childhood cancer face elevated risks of chronic conditions such as diabetes and how digital health tools could help detect—and possibly prevent—these diseases earlier.
Using dollar stores for food purchases may be a common practice for Americans looking to free up funds for the rest of their grocery list, researchers from Tufts University and the USDA-Economic Research Service report. Their multi-year analysis of where households buy their non-restaurant calories found that dollar store food purchases are rising, but families are balancing this with purchasing more nutritious items elsewhere.
A UNSW analysis of Sydney water has found at least 31 PFAS chemicals, including 21 not previously recorded in Australian tap water, and one detected in tap water globally for the first time.
To try to solve the puzzle of how the infection persisted and spread over thousands of years in Eurasia, an international team of researchers from the Max Planck Institute of Infection Biology, Harvard University, the University of Arkansas, the Max Planck Institute of Evolutionary Anthropology, and Seoul National University investigated the bones and teeth of Bronze Age livestock at the pastoralist site Arkaim (Russia), a Eurasian Steppe site belonging to the Sintashta-Petrovka culture known for its innovations in cattle, sheep, and horse husbandry. There they identified a 4,000-year-old sheep infected with the same LNBA lineage of Y. pestis that was infecting people at the time.