Findings connect Fusobacterium nucleatum with multiple sclerosis disease severity

Diabetic kidney disease is a leading cause of kidney failure worldwide, yet current treatments often slow progression sustained improvement in kidney function being uncommon.

Understanding how cells decide their fate is a central challenge in biology, complicated by the fact that single-cell RNA sequencing captures only static snapshots of highly complex and dynamic changes in cell state. In a recent study, researchers from Japan developed a computational method, called ddHodge, that can accurately reconstruct cell state dynamics, shedding light on how genes drive cell fate decisions. Their technique could be useful in developmental biology, regenerative medicine, and cancer research.

Researchers at the MRC Laboratory of Medical Sciences (LMS) and Imperial College London in London, UK have developed a technology that integrates heart-imaging data with information from biological databases to uncover new genes and drugs linked to heart disease. The tool, called CardioKG, is explored in a paper published today in Nature Cardiovascular Research and could accelerate the discovery of new drugs for treating heart conditions.

A new international study led by the Gray Faculty of Medical & Health Sciences at Tel Aviv University finds: melanoma cancer cells paralyze immune cells by secreting extracellular vesicles (EVs), which are tiny, bubble-shaped containers secreted from a given cell. The research team believes that this discovery has far-reaching implications for possible treatments for the deadliest form of skin cancer.

Singapore has one of the highest life expectancies in the world, yet many individuals spend almost a decade in poor health toward the end of life. Scientists from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) are working to understand how ageing itself can be modified to prevent age-related diseases, including Alzheimer’s disease.

The therapeutic use of human calcitonin (CT) in humans is limited by rapid receptor desensitization (tachyphylaxis), which requires short-term dosing despite the need for long-term treatment. In contrast, fish CT-CT receptors (CTR) exhibit extraordinary resistance to desensitization, enabling lifelong calcium regulation in high-Ca²⁺ marine environments. Here, we analyze the evolutionary, structural, and functional distinctions between fish and human CT systems. We propose that the unique molecular structure of fish CT and CTR may provide templates for engineering durable therapeutic agents to overcome tachyphylaxis.

Study shows tooth loss, not low-protein intake, drives memory decline in aging mice, hinting that reduced chewing may influence brain health.