A new machine-learning-based approach to mapping real-time tumor metabolism in brain cancer patients, developed at the University of Michigan, could help doctors discover which treatment strategies are most likely to be effective against individual cases of glioma. The team verified the accuracy of the model by comparing it against human patient data and running mouse experiments.

About The Study: In this cohort study of students in grades 4 through 12, social media’s association with adolescent well-being was complex and nonlinear, varying by age and sex. While heavy use was associated with poorer well-being and abstinence sometimes coincided with less favorable outcomes, these findings are observational and should be interpreted cautiously. 

A team from the eHealth Lab research group at the Universitat Oberta de Catalunya (UOC) has carried out a study to identify the most important criteria for patients when using apps for the treatment of depression. The goal of this research is to develop a digital solution, to be called EvalDepApps, that will evaluate apps for managing depression and help patients and health professionals to choose the most appropriate tool to support their treatment. A team from the eHealth Lab research group at the Universitat Oberta de Catalunya (UOC) has carried out a study to identify the most important criteria for patients when using apps for the treatment of depression. The goal of this research is to develop a digital solution, to be called EvalDepApps, that will evaluate apps for managing depression and help patients and health professionals to choose the most appropriate tool to support their treatment.

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for therapeutics. Among them, the Y220C mutation is the ninth most frequent and it creates a small crevice in the mutant protein that is not present in the wild type conformation. This druggable cavity has led to the development of small molecules such as rezatapopt that are designed to restore p53 and reactivate its normal tumor suppressor function. Rezatapopt has shown promising efficacy in early studies, but as with most targeted therapies, patients can eventually develop resistance to treatment.

Through its commitment to a data-driven approach to improving cardiovascular health, JACC, the flagship journal of the American College of Cardiology, today published the first JACC Cardiovascular Statistics report. This comprehensive analysis examines five major cardiovascular disease (CVD) risk factors - hypertension, diabetes, obesity, LDL-cholesterol and cigarette smoking - and the five conditions that collectively account for most CVD deaths and disability in America: coronary heart disease (CHD), acute myocardial infarction (AMI), heart failure (HF), peripheral artery disease (PAD) and stroke.