Instructions for building antibodies decoded
Universitatsklinikum BonnPeer-Reviewed Publication
MOG Antibody-associated Disease (MOGAD) is a rare autoimmune disease of the central nervous system. The blood of patients contains antibodies against myelin oligodendrocyte glycoprotein (MOG), a protein in the myelin layer that surrounds the neurons in the brain. It is believed that these antibodies contribute to the destruction of this protective layer in the brain. Researchers at the University Hospital Bonn (UKB) and the Universities of Basel and Bonn, in collaboration with Yale School of Medicine and the German Center for Neurodegenerative Diseases (DZNE), have now deciphered the construction plan of the anti-MOG antibodies. The researchers see their findings on the misdirected immune response, which have now been published in the journal Neurology® Neuroimmunology & Neuroinflammation, as the basis for developing specific MOGAD therapies.
- Journal
- Neurology Neuroimmunology & Neuroinflammation