Researchers studying 5556 participants in a Chinese endoscopy-screened cohort found that genetic risk and lifestyle independently and jointly influenced upper gastrointestinal cancer risk. The study identified a potential new gastric cancer susceptibility locus at 6p12.1 from genome-wide association study and showed that adding polygenic risk scores to conventional risk models improved risk stratification. A healthy lifestyle reduced risk across genetic risk groups, with greater benefit among those at high genetic risk.

A retrospective study of 17 drug-resistant epilepsy patients found that stereo-electroencephalography-guided radiofrequency thermocoagulation (RF-TC) rapidly altered brain network connectivity after treatment. Reductions in alpha-band connectivity within epileptogenic regions were linked to clinical outcomes, suggesting that short resting-state recordings may help predict treatment response. Findings support RF-TC as a network-modulating therapy rather than a purely local lesioning procedure and highlight its potential role in guiding more personalized epilepsy care.

In recent years, dengue transmission in Vietnam has transitioned from predictable seasonality to climate-driven instability due to rising temperatures, urbanization, and hydrological extremes, among other factors. Traditional early warning systems based on case averages are becoming increasingly unreliable because of climate non-stationarity, resulting in both false alarms and missed warnings. This perspective summarizes available research on temperature, drought, rainfall extremes, diurnal temperature range, heatwaves, and El Niño anomalies, highlighting biologically-based thresholds that have been observed to precede outbreaks. We advocate for a pragmatic, hybrid early warning system that combines probabilistic national models with operationally simple meteorological triggers adapted to localized conditions. Integrating One Health factors, such as water storage practices, urban livestock habitats, and climate-sensitive vector control technologies, can facilitate optimal responses. This climate-informed, trigger-based approach helps to provide a realistic dengue control and prevention strategy that navigates low-cost and “no regrets” interventions in the face of accelerated environmental change.

Researchers found that FK‑23, a lactic acid bacterium-derived material, improved the sperm dysfunction induced by bisphenol A (BPA)—a chemical commonly used in plastic production including food containers—using a rat model.

By reading full-length RNA molecules one at a time, the method helps scientists see how RNA folds and behaves, offering new clues for disease research and drug discovery.