External validation of the feeding intolerance prediction model (NOFI) in critically ill patients: A post hoc analysis of a large-scale randomized controlled trial
Peer-Reviewed Publication
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Post hoc analysis of a multicenter cluster-RCT (NEED; 97 ICUs, China) validated the NOFI feeding intolerance prediction model in 1,545 ICU patients started on early enteral nutrition within 48 h and fed ≥ 3 days. NOFI uses primary diagnosis, APACHE II, and AGI grade. Performance was assessed by discrimination, calibration, and clinical utility (DCA/CIC). Risk strata: > 0.85 high, 0.30–0.85 middle, < 0.30 low. High-risk patients had higher 28-day mortality.
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