Penicillin–streptomycin influences macrophage mechanical properties and microenvironment mechano-sensation
Peer-Reviewed Publication
Updates every hour. Last Updated: 19-Jun-2026 11:15 ET (19-Jun-2026 15:15 GMT/UTC)
A foundational finding in mechanobiology reveals that penicillin-streptomycin (pen-strep), the antibiotic mixture universally added to mammalian cell culture media, is not a biologically inert antimicrobial agent—but a modulator that directly reshapes macrophage mechanical properties, microenvironmental mechanosensing, and core innate immune functions. Published in the open-access mechanobiology flagship journal Mechanobiology in Medicine, the study by researchers from Sichuan University uncovers a critical, previously unrecognized confounding variable in mechanobiology and immunology research, and prompts a re-evaluation of pen-strep’s use in both lab studies and clinical applications where cellular mechanical function is key.
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