A collaborative team led by Bing Li from Shanghai Jiao Tong University School of Medicine published an article titled "BCL7A’s arginine anchor links nucleosome recognition to chromatin remodeling and diffuse large B-cell lymphoma tumor suppression" in Protein & Cell. This study demonstrates that the conserved arginine anchor within the N-terminal α-helix of BCL7A is crucial for its function across all genomic contexts. This anchor acts as a key molecular switch connecting nucleosome binding to chromatin remodeling and tumor suppression, positioning it as a potential therapeutic target for DLBCL.

Choosing the optimal donor for severe aplastic anemia remains a key challenge in stem cell transplantation. In a large multicenter study of 795 patients in China, researchers found that donor age had a stronger impact on long-term survival than genetic matching. Younger haploidentical donors achieved outcomes comparable to, and in some cases better than, older fully matched sibling donors, suggesting donor age should be prioritized in clinical decision-making.