This study focuses on platinum-based chemotherapy-induced cardiotoxicity, covering its mechanisms, manifestations, detection, management, and future directions. Mechanisms include oxidative stress, direct myocardial/DNA damage, mitochondrial dysfunction, and altered signaling (e.g., MAPK, PI3K/Akt). Manifestations range from asymptomatic left ventricular dysfunction to severe conditions like heart failure and Takotsubo cardiomyopathy. Detection relies on advanced imaging (echocardiography with GLS, CMR) and biomarkers (cardiac troponins). Management involves cardioprotective agents (ACEIs, β-blockers) and regimen adjustment. Innovations include nanoliposomal/cubosomal formulations, iPSC-derived cardiomyocyte screening, zebrafish models, and in silico modeling. Clinically, it emphasizes multidisciplinary collaboration and early monitoring to balance cancer therapy efficacy and cardiac safety.

This review systematically synthesizes the classification (melanoma skin cancer [MSC], non-melanoma skin cancers [NMSCs]) and global epidemiology of skin cancer based on 2000–2024 literature. MSC, ranking 17th in global prevalence, has the highest incidence and mortality in Europe; NMSCs, 18–20 times more prevalent than MSC and accounting for more skin cancer deaths, show the highest incidence in North America and mortality in Asia. Australia and New Zealand exhibit the highest overall skin cancer incidence. Superficial spreading melanoma is the most common MSC subtype; basal cell carcinoma (BCC) is the most prevalent NMSC, while squamous cell carcinoma (SCC) is the deadliest NMSC.

Its innovation lies in comprehensive continental and subtype-specific epidemiological profiling. Clinically, it highlights the need to standardize incidence/prevalence reporting, investigate rare subtypes (e.g., uveal melanoma), enhance early detection, and apply telemedicine/AI to optimize diagnosis, particularly in resource-limited settings.

Rapid and urgent action on food is needed if the UK is to reboot its flagging economy, save the NHS billions, ensure national food security, and meet climate commitments, according to a new report.

The Roadmap for Resilience: A UK Food Plan for 2050, calls for radical transformation, at a scale and pace not seen since the Second World War. It says if we do not act now, change will be forced upon us by increasing pressures and the UK will lurch from crisis to crisis, including from food price shocks, climate disasters and weakening economic productivity.