The ability of CD8⁺ T cells, a type of immune cell, to rapidly proliferate inside tumors is key to the success of cancer immunotherapy. In a new study, scientists from Tokyo University of Science, Japan, have identified a set of ‘signature’ genes that can determine whether these immune cells will multiply or stall within the tumor. Their findings provide a powerful pan-immunotherapy biomarker for treatment monitoring and pave the way for next-generation immunodynamic therapies.

Type 2 diabetes is surging in children, now making up 24% to 45% of youth diabetes cases – up from just 1% to 2% before the mid-1990s. While obesity remains the top risk factor, new research shows early-life environments also play a powerful role. Analyzing data on more than 174,000 children nationwide, including 50,000 under age 5, the study shows that factors like poor neighborhood walkability, food insecurity, caregiver health, and exposure to processed foods through assistance programs were strongly linked to diabetes risk.