A landmark study among more than 100,000 Queensland residents has revealed that while the incidence of developing second primary invasive cutaneous melanomas increased from the 1980s through the early 2000s, the rising trend has now begun to plateau. The reassuring findings of the new study in the Journal of Investigative Dermatology (JID), published by Elsevier, can be mainly attributed to the cumulative impact of long-running sun safety campaigns in Australia combined with increased surveillance.

Lynch Syndrome (LS) is a hereditary condition involving mutations in DNA mismatch repair genes

Researchers sequenced T cell receptors in blood and tissue samples from LS carriers and non-carriers and characterized their T cell profiles

Study revealed unique early immune signatures in patients with LS, independent of cancer history

Blood test could serve as non-invasive tool for early cancer detection and monitoring of immune response to cancer