Sepsis can leave survivors with lasting brain symptoms. Researchers report that ANXA2, a protein in the brain's immune cells, may act like an inflammation amplifier after sepsis. They designed a dual-targeted lipid carrier to bring evodiamine into the brain and microglia, easing inflammation and improving behavior and memory in mice.

Researchers identified two opposing tumor-associated macrophage states that regulate T cell interferon signaling and immunotherapy response in gastric cancer. An interferon-responsive immune niche predicts improved outcomes, while lipid-driven macrophages suppress T cell function and contribute to resistance.

_{Depression and obesity are major global health burdens, yet the co-occurrence patterns and temporal trends of their comorbidity remain poorly characterised at the global level. To map the global patterns of co-occurring depression and obesity, quantify temporal trends of depression, obesity and comorbidity, forecast the prevalence of comorbidity up to 2035 and compare social indicators across groups stratified by their combined temporal trends of depression and obesity.}