Cracking leishmaniasis: new DNA test to track infection
Peer-Reviewed Publication
Updates every hour. Last Updated: 14-Jan-2026 15:11 ET (14-Jan-2026 20:11 GMT/UTC)
A new study offers an innovative way to track the spread of leishmaniasis, a parasitic disease affecting both animals and humans. Using high-resolution melting (HRM) PCR, researchers developed a fast, reliable method to identify sand fly species, detect Leishmania parasites, and determine the source of their blood meals from a single sample. The study mapped twelve sand fly species, four Leishmania species, and twenty-five host animals across Israel, revealing complex patterns of transmission. This approach provides a powerful new tool for veterinarians and public health authorities to monitor and control zoonotic diseases more effectively.
Researchers from Shandong University have engineered CYP152 peroxygenases for a green, efficient, and enantioselective one-step synthesis of (R)-mandelic acid derivatives, offering a sustainable solution for producing chiral molecules in pharmaceuticals and fine chemicals.
A commentary published in Brain Medicine by Drs. Julio Licinio and Ma-Li Wong examines groundbreaking research identifying adenosine signaling as the convergent mechanism underlying rapid-acting antidepressant therapies. The analysis synthesizes the recent Nature study by Yue and colleagues led by Professor Min-Min Luo, which unified the therapeutic effects of ketamine, electroconvulsive therapy, and acute intermittent hypoxia through adenosine surges in mood-regulatory brain circuits. The commentary explores how this metabolic mechanism operates independently of NMDA receptor antagonism, potentially enabling improved derivatives with better therapeutic indices. Most intriguingly, it raises questions about caffeine consumption patterns in treatment-resistant depression, distinguishing between potentially protective effects of chronic coffee drinking and possible interference from acute pre-treatment consumption. This provides a framework for understanding how disparate interventions achieve rapid antidepressant effects.
Researchers compared MRI scans of the brain before and after treating Alzheimer's disease with the amyloid-targeting drug lecanemab. They found no significant short-term changes in waste clearance, highlighting the complexity of the disease.
Researchers from University of Granada and the Spanish National Research Council designed four ideal weekly menus with an equal energy value and following international recommendations for the daily intake of a wide range of macro- and micronutrients. Each menu was in accordance with an omnivorous Mediterranean, pesco-vegetarian, ovo-lacto-vegetarian, or vegan diet. The vegan diet reduced carbon emissions by 46%, water use by 7%, and land use by 33%, while the two vegetarian diets cut carbon emissions by up to 35%. The three plant-based diets were nutritionally balanced, except for small deficits in vitamin D, iodine, and vitamin B12, which can be remedied with supplements. The authors concluded that plant-based diets are equally nutritious and healthy as a Mediterranean diet, and much better for the planet.
In one of the first studies to examine the link between ultra-prcessed food consumption and how the body processes glucose in young people, USC researchers found that an increase in UPF intake was associated with a higher risk for prediabetes, or early-stage high blood sugar that can lead to diabetes. Eating more UPFs was also linked to insulin resistance, where the body becomes less effective at using insulin to control blood sugar. The research included 85 young adults from the Metabolic and Asthma Incidence Research (Meta-AIR) study, part of the broader Southern California Children's Health Study. Participants, aged 17-22, provided data at a baseline visit between 2014 and 2018 and a follow-up visit approximately four years later. At each visit, participants reported everything they had eaten on one recent weekday and one recent weekend day. Researchers classified foods into two categories: UPFs (such as candy, soda, cereal, packaged spreads, flavored yogurts, and many restaurant foods) and foods that were not ultra-processed. They then calculated what percentage of each participant’s daily caloric intake came from UPFs. The researchers also collected blood samples from participants before and after they consumed a sugary drink to test how effectively their body responded to blood sugar with insulin. They then conducted a statistical analysis to compare dietary changes with signs of prediabetes, adjusting for differences in age, sex, ethnicity and physical activity levels. From baseline to follow-up, a 10% increase in UPF consumption was associated with a 64% higher risk for prediabetes and a 56% higher risk for problems with glucose regulation. Participants who reported eating more UPFs at their initial visit were also more likely to have elevated insulin levels at follow-up—an early sign of insulin resistance, where the body must produce more insulin to keep blood sugar in a healthy range