How the internal liver clock orchestrates daily fat secretion
Peer-Reviewed Publication
Updates every hour. Last Updated: 15-Jun-2026 18:16 ET (15-Jun-2026 22:16 GMT/UTC)
Metabolic dysfunction-associated steatotic liver disease (MASLD) is among the most common chronic liver diseases, and, when untreated, can progress to cancer, cardiovascular disease, and diabetes. Salk Institute scientists found that production of a protein called FGF1 in the liver varies throughout the day to affect fat release timing from the liver into the bloodstream, acting as a circadian pacemaker for liver fat metabolism. These findings illuminate a previously unknown circadian lipid trafficking mechanism in the liver, with implications for understanding how disrupted body clocks drive metabolic disease.
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