How bone marrow fat drives immune suppression and bone loss in obesity
Peer-Reviewed Publication
Updates every hour. Last Updated: 19-Jun-2026 11:15 ET (19-Jun-2026 15:15 GMT/UTC)
Obesity alters bone health not only through increased body weight but also by reshaping the bone marrow environment. Researchers show that expansion of bone marrow fat promotes immunosuppressive PD-L1 signaling, which enhances osteoclast formation and accelerates bone loss. By reducing bone marrow fat in mice, they reduced immune suppression and improved bone structure. These findings uncover a new mechanism linking metabolism, immunity, and skeletal health, offering potential therapeutic targets for obesity-related bone disorders.
Alcohol the default for teens and no/low alternatives uncommon, UK-first study finds
Researchers from the City University of New York (CUNY) Graduate Center and Queens College suggest that building strong adaptive skills in early childhood may serve as a buffer against the detrimental effects of prenatal stress on a child’s developing brain.